Proteintech

SCO2 Polyclonal Antibody

SCO2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SCO2 Antibody (21223-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human hepatocirrhosis using 21223-1-AP (SCO2 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

21223-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SCO2 Fusion Protein Ag15663 (1-266 aa encoded by BC102025)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLLLTRSPT AWHRLSQLKP RVLPGTLGGQ ALHLRSWLLS RQGPAETGGQ GQPQGPGLRT RLLITGLFGA GLGGAWLALR AEKERLQQQK RTEALRQAAV GQGDFHLLDH RGRARCKADF RGQWVLMYFG FTHCPDICPD ELEKLVQVVR QLEAEPGLPP VQPVFITVDP ERDDVEAMAR YVQDFHPRLL GLTGSTKQVA QASHSYRVYY NAGPKDEDQD YIVDHSIAIY LLNPDGLFTD YYGRSRSAEQ ISDSVRRHMA AFRSVLS (1-266 aa encoded by BC102025)

Target Information

Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Expression of SCO1 and SCO2 after form-deprivation myopia in Guinea pigs.

European journal of ophthalmology

Zhou G,Lan C,Yang Q,Zhong W,Gu Z,Xiang X,Mao Y,Liao X

Thu Sep 01 00:00:00 UTC 2022

Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production.

Cell death and differentiation

Yin K,Lee J,Liu Z,Kim H,Martin DR,Wu D,Liu M,Xue X

Sun Aug 01 00:00:00 UTC 2021

SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.

International journal of molecular sciences

Ramos H,Calheiros J,Almeida J,Barcherini V,Santos S,Carvalho ATP,Santos MMM,Saraiva L

Fri Jan 17 00:00:00 UTC 2020

SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.

International journal of molecular sciences

Ramos H,Calheiros J,Almeida J,Barcherini V,Santos S,Carvalho ATP,Santos MMM,Saraiva L

Fri Jan 17 00:00:00 UTC 2020

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

EMBO molecular medicine

Signes A,Cerutti R,Dickson AS,Benincá C,Hinchy EC,Ghezzi D,Carrozzo R,Bertini E,Murphy MP,Nathan JA,Viscomi C,Fernandez-Vizarra E,Zeviani M

Tue Jan 01 00:00:00 UTC 2019

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

EMBO molecular medicine

Signes A,Cerutti R,Dickson AS,Benincá C,Hinchy EC,Ghezzi D,Carrozzo R,Bertini E,Murphy MP,Nathan JA,Viscomi C,Fernandez-Vizarra E,Zeviani M

Tue Jan 01 00:00:00 UTC 2019

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.

Oncotarget

Liu F,Zhang W,You X,Liu Y,Li Y,Wang Z,Wang Y,Zhang X,Ye L

Tue Sep 29 00:00:00 UTC 2015

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.

Oncotarget

Liu F,Zhang W,You X,Liu Y,Li Y,Wang Z,Wang Y,Zhang X,Ye L

Tue Sep 29 00:00:00 UTC 2015

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.

Oncotarget

Liu F,Zhang W,You X,Liu Y,Li Y,Wang Z,Wang Y,Zhang X,Ye L

Tue Sep 29 00:00:00 UTC 2015

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.

Oncotarget

Liu F,Zhang W,You X,Liu Y,Li Y,Wang Z,Wang Y,Zhang X,Ye L

Tue Sep 29 00:00:00 UTC 2015

Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Cell metabolism

Pacheu-Grau D,Bareth B,Dudek J,Juris L,Vögtle FN,Wissel M,Leary SC,Dennerlein S,Rehling P,Deckers M

Tue Jun 02 00:00:00 UTC 2015

Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.

PloS one

Napoli E,Ross-Inta C,Wong S,Hung C,Fujisawa Y,Sakaguchi D,Angelastro J,Omanska-Klusek A,Schoenfeld R,Giulivi C

Fri Mar 22 00:00:00 UTC 2013

Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.

PloS one

Napoli E,Ross-Inta C,Wong S,Hung C,Fujisawa Y,Sakaguchi D,Angelastro J,Omanska-Klusek A,Schoenfeld R,Giulivi C

Fri Mar 22 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2

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Gene Aliases: CEMCOX1; MYP6; SCO1L; SCO2

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UniProt ID: (Human) O43819

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Entrez Gene ID: (Human) 9997

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Function(s)

copper ion binding protein binding

Process(es)

eye development in utero embryonic development muscle system process copper ion transport cellular copper ion homeostasis respiratory chain complex IV assembly response to activity respiratory electron transport chain cell redox homeostasis oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SCO2 Polyclonal Antibody

SCO2 Antibody (21223-1-AP) in IHC (P)

Product Details

21223-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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