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          • Primary Antibodies ›
          • SCP2 Antibodies

          Bioss

          SCP2/NLTP Polyclonal Antibody

          View all (22) SCP2 antibodies

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          Cite SCP2/NLTP Polyclonal Antibody

          Product Details

          BS-2014R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human SCP2/NLTP, amino acids 451-547.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; nonspecific lipid transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCP-X; SCPX; Sterol carrier protein 2; Sterol carrier protein 2, liver; Sterol carrier protein X

          View more View less

          Gene Aliases: AA409774; AA409893; C76618; C79031; NLTP; ns-LTP; NSL-TP; NSLIPTR; SCP-2; SCP-CHI; SCP-X; SCP2; SCPX

          View more View less

          UniProt ID: (Human) P22307, (Rat) P11915, (Mouse) P32020

          View more View less

          Entrez Gene ID: (Human) 6342, (Rat) 25541, (Mouse) 20280

          View more View less

          Function(s)
          fatty-acyl-CoA binding receptor binding protein binding sterol transporter activity cholesterol binding propanoyl-CoA C-acyltransferase activity long-chain fatty acyl-CoA binding propionyl-CoA C2-trimethyltridecanoyltransferase activity oleic acid binding collagen binding lipid binding phosphatidylinositol transporter activity transferase activity, transferring acyl groups other than amino-acyl groups catalytic activity acetyl-CoA C-acyltransferase activity phosphatidylcholine transporter activity transferase activity transferase activity, transferring acyl groups cholesterol transporter activity protein homodimerization activity protein heterodimerization activity phosphatidylethanolamine transporter activity
          Process(es)
          steroid biosynthetic process progesterone biosynthetic process lipid transport peroxisome organization metabolic process negative regulation of cell proliferation positive regulation of steroid biosynthetic process phospholipid transport negative regulation of cell migration positive regulation of intracellular cholesterol transport inositol trisphosphate biosynthetic process positive regulation of steroid metabolic process protein localization to plasma membrane lipid hydroperoxide transport acyl-CoA metabolic process transport aging cholesterol transport positive regulation of apoptotic process positive regulation of cholesterol biosynthetic process positive regulation of cholesterol import bile acid biosynthetic process sterol transport fatty acid beta-oxidation using acyl-CoA oxidase alpha-linolenic acid metabolic process
          It has to be done as per old AB suggested Products section.
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