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Invitrogen
SCUBE2 Polyclonal Antibody
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Product Details
PA5-56278
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCUBE2. Recombinant protein control fragment (Product #RP-88796).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2647039
Product Specific Information
Immunogen sequence: SGIHLSSDVT TIRTSVTFKL NEGKCSLKNA ELFPEGLRPA LPEKHSSVKE SFRYVNLTCS SGKQVPGAPG RPSTPKEMFI TVEFELETNQ KEVTASCDLS CIVKRTEKRL RKAIRTLRKA VHREQFHLQL SGMNLDVAK
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.
Target Information
SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein CEGP1; Scube/You; signal peptide; Signal peptide, CUB and EGF-like domain-containing protein 2; signal peptide, CUB domain, EGF-like 2
Gene Aliases: CEGB1; CEGF1; CEGP1; SCUBE2
UniProt ID: (Human) Q9NQ36
Entrez Gene ID: (Human) 57758
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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