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OriGene
SDCBP Monoclonal Antibody (OTI2H6), TrueMAB™
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Product Details
CF504796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2H6
Immunogen
Full length human recombinant protein of human SDCBP produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; syndecan binding protein (syntenin); Syndecan-binding protein 1; Syntenin-1; TACIP18
Gene Aliases: MDA-9; MDA9; SDCBP; ST1; SYCL; TACIP18
UniProt ID: (Human) O00560
Entrez Gene ID: (Human) 6386
glycoprotein binding
frizzled binding
interleukin-5 receptor binding
protein binding
protein C-terminus binding
cytoskeletal adaptor activity
growth factor binding
neurexin family protein binding
identical protein binding
protein homodimerization activity
syndecan binding
ephrin receptor binding
protein heterodimerization activity
protein N-terminus binding
cadherin binding involved in cell-cell adhesion
negative regulation of receptor internalization
protein targeting to membrane
substrate-dependent cell migration, cell extension
Ras protein signal transduction
chemical synaptic transmission
regulation of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
actin cytoskeleton organization
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
positive regulation of phosphorylation
positive regulation of JNK cascade
ephrin receptor signaling pathway
cell-cell adhesion
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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