Proteintech

SDPR Polyclonal Antibody

SDPR Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 20

SDPR Antibody (12339-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed A549 cells using 12339-1-AP (SDPR antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SDPR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SDPR Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12339-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SDPR Fusion Protein Ag2990 (73-426 aa encoded by BC016475)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This is a rabbit polyclonal SDPR antibody raised against the C-terminus of human SDPR. SDRP of molecular masses 115 kDa and 100 kDa were found in neutrophils, monocytes, lymphocytes, platelets and erythrocytes. In platelets, however, the principal SDRP is a cytosolic protein of molecular mass 68 kDa.

Immunogen sequence: QENQHKMEQ RQISLEGSVK GIQNDLTKLS KYQASTSNTV SKLLEKSRKV SAHTRAVKER MDRQCAQVKR LENNHAQLLR RNHFKVLIFQ EENEIPASVF VKQPVSGAVE GKEELPDENK SLEETLHTVD LSSDDDLPHD EEALEDSAEE KVEESRAEKI KRSSLKKVDS LKKAFSRQNI EKKMNKLGTK IVSVERREKI KKSLTSNHQK ISSGKSSPFK VSPLTFGRKK VREGESHAEN ETKSEDLPSS EQMPNDQEEE SFAEGHSEAS LASALVEGEI AEEAAEKATS RGSNSGMDSN IDLTIVEDEE EESVALEQAQ KVRYEGSYAL TSEEAERSDG DPVQPAVLQV HQTS (73-426 aa encoded by BC016475)

Target Information

The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.

Molecular metabolism

Higuchi Y,Ogata T,Nakanishi N,Nishi M,Sakamoto A,Tsuji Y,Tomita S,Matoba S

Sat Jan 01 00:00:00 UTC 2022

Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.

Molecular metabolism

Higuchi Y,Ogata T,Nakanishi N,Nishi M,Sakamoto A,Tsuji Y,Tomita S,Matoba S

Sat Jan 01 00:00:00 UTC 2022

Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.

Molecular metabolism

Higuchi Y,Ogata T,Nakanishi N,Nishi M,Sakamoto A,Tsuji Y,Tomita S,Matoba S

Sat Jan 01 00:00:00 UTC 2022

UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1.

Cell communication and signaling : CCS

Cen X,Chen Q,Wang B,Xu H,Wang X,Ling Y,Zhang X,Qin D

Mon Nov 28 00:00:00 UTC 2022

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq.

Developmental cell

Ulrich ND,Shen YC,Ma Q,Yang K,Hannum DF,Jones A,Machlin J,Randolph JF,Smith YR,Schon SB,Shikanov A,Marsh EE,Lieberman R,Gurczynski SJ,Moore BB,Li JZ,Hammoud S

Mon Apr 11 00:00:00 UTC 2022

Prognostic values, ceRNA network, and immune regulation function of SDPR in KRAS-mutant lung cancer.

Cancer cell international

Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

Tue Jan 12 00:00:00 UTC 2021

Prognostic values, ceRNA network, and immune regulation function of SDPR in KRAS-mutant lung cancer.

Cancer cell international

Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

Tue Jan 12 00:00:00 UTC 2021

Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.

ACS nano

Liao Z,Liu H,Ma L,Lei J,Tong B,Li G,Ke W,Wang K,Feng X,Hua W,Li S,Yang C

Tue Sep 28 00:00:00 UTC 2021

EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis.

Molecular biology of the cell

Tiruppathi C,Regmi SC,Wang DM,Mo GCH,Toth PT,Vogel SM,Stan RV,Henkemeyer M,Minshall RD,Rehman J,Malik AB

Fri May 15 00:00:00 UTC 2020

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.

Haematologica

Eaton N,Drew C,Wieser J,Munday AD,Falet H

Fri May 01 00:00:00 UTC 2020

Cavin-2 is a specific marker for detection of well-differentiated liposarcoma.

Biochemical and biophysical research communications

Codenotti S,Vezzoli M,Poliani PL,Cominelli M,Monti E,Fanzani A

Sat Nov 04 00:00:00 UTC 2017

Cavin-2 is a specific marker for detection of well-differentiated liposarcoma.

Biochemical and biophysical research communications

Codenotti S,Vezzoli M,Poliani PL,Cominelli M,Monti E,Fanzani A

Sat Nov 04 00:00:00 UTC 2017

Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis.

The Journal of biological chemistry