Proteintech

SEC13 Polyclonal Antibody

SEC13 Antibody in Immunocytochemistry (ICC/IF)

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SEC13 Antibody (15397-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 15397-1-AP (SEC13 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SEC13 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SEC13 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15397-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SEC13 Fusion Protein Ag7610 (1-325 aa encoded by BC002634)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGKMVSVIN TVDTSHEDMI HDAQMDYYGT RLATCSSDRS VKIFDVRNGG QILIADLRGH EGPVWQVAWA HPMYGNILAS CSYDRKVIIW REENGTWEKS HEHAGHDSSV NSVCWAPHDY GLILACGSSD GAISLLTYTG EGQWEVKKIN NAHTIGCNAV SWAPAVVPGS LIDHPSGQKP NYIKRFASGG CDNLIKLWKE EEDGQWKEEQ KLEAHSDWVR DVAWAPSIGL PTSTIASCSQ DGRVFIWTCD DASSNTWSPK LLHKFNDVVW HVSWSITANI LAVSGGDNKV TLWKESVDGQ WVCISDVNKG QGSVSASVTE GQQNEQ (1-325 aa encoded by B C002634)

Target Information

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.

bioRxiv : the preprint server for biology

Danan CH,Naughton KE,Hayer KE,Vellappan S,McMillan EA,Zhou Y,Matsuda R,Nettleford SK,Katada K,Parham LR,Ma X,Chowdhury A,Wilkins BJ,Shah P,Weitzman MD,Hamilton KE

Fri Apr 21 00:00:00 UTC 2023

Ring domains are essential for GATOR2-dependent mTORC1 activation.

Molecular cell

Jiang C,Dai X,He S,Zhou H,Fang L,Guo J,Liu S,Zhang T,Pan W,Yu H,Fu T,Li D,Inuzuka H,Wang P,Xiao J,Wei W

Thu Jan 05 00:00:00 UTC 2023

Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length.

Frontiers in cell and developmental biology

Kliszczak M,Moralli D,Jankowska JD,Bryjka P,Subha Meem L,Goncalves T,Hester SS,Fischer R,Clynes D,Green CM

Sat Jul 01 00:00:00 UTC 2023

GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.

JCI insight

Morales J,Allegakoen DV,Garcia JA,Kwong K,Sahu PK,Fajardo DA,Pan Y,Horlbeck MA,Weissman JS,Gustafson WC,Bivona TG,Sabnis AJ

Thu Dec 08 00:00:00 UTC 2022

Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.

Nature communications

Chen X,Yu C,Liu X,Liu B,Wu X,Wu J,Yan D,Han L,Tang Z,Yuan X,Wang J,Wang Y,Liu S,Shan L,Shang Y

Thu Dec 08 00:00:00 UTC 2022

Structure of the nutrient-sensing hub GATOR2.

Nature

Valenstein ML,Rogala KB,Lalgudi PV,Brignole EJ,Gu X,Saxton RA,Chantranupong L,Kolibius J,Quast JP,Sabatini DM

Fri Jul 01 00:00:00 UTC 2022

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

Redox biology

You M,Wu F,Gao M,Chen M,Zeng S,Zhang Y,Zhao W,Li D,Wei L,Ruan XZ,Chen Y

Tue Nov 01 00:00:00 UTC 2022

DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.

Oncogene

Chen B,Xu F,Gao Y,Hu G,Zhu K,Lu H,Xu A,Chen S,Wu L,Zhao G

Tue Mar 01 00:00:00 UTC 2022

Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.

Proceedings of the National Academy of Sciences of the United States of America

Niu L,Ma T,Yang F,Yan B,Tang X,Yin H,Wu Q,Huang Y,Yao ZP,Wang J,Guo Y,Hu J

Tue Jul 09 00:00:00 UTC 2019

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

eLife

Kane M,Rebensburg SV,Takata MA,Zang TM,Yamashita M,Kvaratskhelia M,Bieniasz PD

Tue Aug 07 00:00:00 UTC 2018

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

eLife

Kane M,Rebensburg SV,Takata MA,Zang TM,Yamashita M,Kvaratskhelia M,Bieniasz PD

Tue Aug 07 00:00:00 UTC 2018

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.

Proceedings of the National Academy of Sciences of the United States of America

Hanna MG,Block S,Frankel EB,Hou F,Johnson A,Yuan L,Knight G,Moresco JJ,Yates JR,Ashton R,Schekman R,Tong Y,Audhya A

Tue Sep 12 00:00:00 UTC 2017

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments.

Proceedings of the National Academy of Sciences of the United States of America

Hanna MG,Block S,Frankel EB,Hou F,Johnson A,Yuan L,Knight G,Moresco JJ,Yates JR,Ashton R,Schekman R,Tong Y,Audhya A

Tue Sep 12 00:00:00 UTC 2017

Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons.

Neurobiology of disease

Teodorof C,Divakar S,Soontornniyomkij B,Achim CL,Kaul M,Singh KK

Mon Sep 01 00:00:00 UTC 2014

Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons.

Neurobiology of disease

Teodorof C,Divakar S,Soontornniyomkij B,Achim CL,Kaul M,Singh KK

Mon Sep 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: GATOR2 complex protein SEC13; Protein SEC13 homolog; SEC13 homolog; SEC13 homolog, nuclear pore and COPII coating complex component; SEC13 related; SEC13-like 1; SEC13-like 1 isoform; SEC13-like protein 1; SEC13-related protein

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Gene Aliases: 1110003H02Rik; D3S1231E; npp-20; SEC13; SEC13A; SEC13L1; SEC13R

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UniProt ID: (Human) P55735, (Mouse) Q9D1M0, (Rat) Q5XFW8

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Entrez Gene ID: (Human) 6396, (Mouse) 110379, (Rat) 297522

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Function(s)

protein binding

Process(es)

antigen processing and presentation of peptide antigen via MHC class I intracellular protein transport sister chromatid cohesion antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of TOR signaling COPII vesicle coating mRNA transport transport ER to Golgi vesicle-mediated transport protein transport vesicle-mediated transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SEC13 Polyclonal Antibody

SEC13 Antibody (15397-1-AP) in ICC/IF

Product Details

15397-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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