Proteintech

SEC24A Polyclonal Antibody

SEC24A Antibody in Immunocytochemistry (ICC/IF)

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SEC24A Antibody (15958-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using SEC24A antibody 15958-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

SEC24A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

15958-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SEC24A Fusion Protein Ag8723 (264-613 aa encoded by BC019341)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DEIEGGGLL ATPQLTNKNP KMSRSVGYSY PSLPPGYQNI TPPGATGVPP SSLNYPSGPQ AFTQTPLGAN HLTTSMSGLS LQPEGLRVVN LLQERNMLPS TPLKPPVPNL HEDIQKLNCN PELFRCTLTS IPQMQALLNK AKLPLGLLLH PFKDLVQLPV VTSSTIVRCR SCRTYINPFV SFLDQRRWKC NLCYRVNDVP EEFLYNPLTR VYGEPHRRPE VQNATIEFMA PSEYMLRPPQ PPVYLFVFDV SHNAVETGYL NSVCQSLLDN LDLLPGNTRT KIGFITFDST IHFYGLQESL SQPQMLIVSD IEDVFIPMPE NLLVNLNESK ESVIGVSSEE TLITCLEIAM R (264-613 aa encoded by BC019341)

Target Information

SC24A is a component of coat protein II (COPII; see MIM 601924)-coated vesicles that mediate protein transport from the endoplasmic reticulum. SEC24A is 1 of several mammalian proteins that show structural and functional homology to yeast Sec24.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

The Journal of clinical investigation

Liu Z,Yan M,Lei W,Jiang R,Dai W,Chen J,Wang C,Li L,Wu M,Nian X,Li D,Sun D,Lv X,Wang C,Xie C,Yao L,Wu C,Hu J,Xiao N,Mo W,Wang Z,Zhang L

Fri Apr 01 00:00:00 UTC 2022

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

The Journal of clinical investigation

Liu Z,Yan M,Lei W,Jiang R,Dai W,Chen J,Wang C,Li L,Wu M,Nian X,Li D,Sun D,Lv X,Wang C,Xie C,Yao L,Wu C,Hu J,Xiao N,Mo W,Wang Z,Zhang L

Fri Apr 01 00:00:00 UTC 2022

A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.

Cell reports

Stomberski CT,Venetos NM,Zhou HL,Qian Z,Collison BR,Field SJ,Premont RT,Stamler JS

Tue Oct 25 00:00:00 UTC 2022

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

Redox biology

You M,Wu F,Gao M,Chen M,Zeng S,Zhang Y,Zhao W,Li D,Wei L,Ruan XZ,Chen Y

Tue Nov 01 00:00:00 UTC 2022

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

Redox biology

You M,Wu F,Gao M,Chen M,Zeng S,Zhang Y,Zhao W,Li D,Wei L,Ruan XZ,Chen Y

Tue Nov 01 00:00:00 UTC 2022

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

Redox biology

You M,Wu F,Gao M,Chen M,Zeng S,Zhang Y,Zhao W,Li D,Wei L,Ruan XZ,Chen Y

Tue Nov 01 00:00:00 UTC 2022

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis.

Redox biology

You M,Wu F,Gao M,Chen M,Zeng S,Zhang Y,Zhao W,Li D,Wei L,Ruan XZ,Chen Y

Tue Nov 01 00:00:00 UTC 2022

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Journal for immunotherapy of cancer

Li C,Chi H,Deng S,Wang H,Yao H,Wang Y,Chen D,Guo X,Fang JY,He F,Xu J

Sun Aug 01 00:00:00 UTC 2021

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Journal for immunotherapy of cancer

Li C,Chi H,Deng S,Wang H,Yao H,Wang Y,Chen D,Guo X,Fang JY,He F,Xu J

Sun Aug 01 00:00:00 UTC 2021

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Journal for immunotherapy of cancer

Li C,Chi H,Deng S,Wang H,Yao H,Wang Y,Chen D,Guo X,Fang JY,He F,Xu J

Sun Aug 01 00:00:00 UTC 2021

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

The Journal of clinical investigation

Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M

Wed Aug 01 00:00:00 UTC 2018

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

The Journal of clinical investigation

Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M

Wed Aug 01 00:00:00 UTC 2018

Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection.

Frontiers in immunology

Möllerherm H,Branitzki-Heinemann K,Brogden G,Elamin AA,Oehlmann W,Fuhrmann H,Singh M,Naim HY,von Köckritz-Blickwede M

Wed Nov 20 00:00:00 UTC 2019

Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection.

Frontiers in immunology

Möllerherm H,Branitzki-Heinemann K,Brogden G,Elamin AA,Oehlmann W,Fuhrmann H,Singh M,Naim HY,von Köckritz-Blickwede M

Wed Nov 20 00:00:00 UTC 2019

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

Nature

Han J,Li E,Chen L,Zhang Y,Wei F,Liu J,Deng H,Wang Y

Thu Aug 13 00:00:00 UTC 2015

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

Nature

Han J,Li E,Chen L,Zhang Y,Wei F,Liu J,Deng H,Wang Y

Thu Aug 13 00:00:00 UTC 2015

Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection.

PLoS pathogens

Taguchi Y,Imaoka K,Kataoka M,Uda A,Nakatsu D,Horii-Okazaki S,Kunishige R,Kano F,Murata M

Sun Mar 01 00:00:00 UTC 2015

Yip1A, a novel host factor for the activation of the IRE1 pathway of the unfolded protein response during Brucella infection.

PLoS pathogens

Taguchi Y,Imaoka K,Kataoka M,Uda A,Nakatsu D,Horii-Okazaki S,Kunishige R,Kano F,Murata M

Sun Mar 01 00:00:00 UTC 2015

The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.

Cell metabolism

Gustafsen C,Kjolby M,Nyegaard M,Mattheisen M,Lundhede J,Buttenschøn H,Mors O,Bentzon JF,Madsen P,Nykjaer A,Glerup S

Tue Feb 04 00:00:00 UTC 2014

The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.

Cell metabolism

Gustafsen C,Kjolby M,Nyegaard M,Mattheisen M,Lundhede J,Buttenschøn H,Mors O,Bentzon JF,Madsen P,Nykjaer A,Glerup S

Tue Feb 04 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Protein transport protein Sec24A; SEC24 family member A; SEC24 family, member A; SEC24 related gene family, member A; SEC24-related protein A

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Gene Aliases: SEC24A

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UniProt ID: (Human) O95486, (Mouse) Q3U2P1

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Entrez Gene ID: (Human) 10802, (Mouse) 77371, (Rat) 287275

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Function(s)

molecular_function protein binding zinc ion binding

Process(es)

transport intracellular protein transport ER to Golgi vesicle-mediated transport protein transport vesicle-mediated transport regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of protein secretion positive regulation of cholesterol homeostasis antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class II COPII vesicle coating

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SEC24A Polyclonal Antibody

SEC24A Antibody (15958-1-AP) in ICC/IF

Product Details

15958-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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