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SEC61G Polyclonal Antibody

SEC61G Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SEC61G Antibody (11147-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 11147-2-AP (SEC61G antibody) at dilution of 1:50 (under 10x lens).

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Product Details

11147-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SEC61G Fusion Protein Ag1624 (1-68 aa encoded by BC009480)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize endogenous SEC61G that migrates at a molecular mass of ~8 kDa.

Immunogen sequence: MDQVMQFVE PSRQFVKDSI RLVKRCTKPD RKEFQKIAMA TAIGFAIMGF IGFFVKLIHI PINNIIVGG (1-68 aa encoded by BC009480)

Target Information

SEC61G is a subunit of the SEC61 complex, which also contains alpha (SEC61A) and beta (SEC61B) subunits. The SEC61 complex is the central component of the protein translocation apparatus on the endoplasmic reticulum membrane. The gene of SEC61G maps to chromosome 7p11.2, and encodes a 68-amino acid single-pass membrane protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.

British journal of cancer

Xu S,Li X,Geng J,Cao Y,Yu Y,Qi L

Sat Apr 01 00:00:00 UTC 2023

Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.

British journal of cancer

Xu S,Li X,Geng J,Cao Y,Yu Y,Qi L

Sat Apr 01 00:00:00 UTC 2023

Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.

British journal of cancer

Xu S,Li X,Geng J,Cao Y,Yu Y,Qi L

Sat Apr 01 00:00:00 UTC 2023

Mechanism of an intramembrane chaperone for multipass membrane proteins.

Nature

Smalinskaitė L,Kim MK,Lewis AJO,Keenan RJ,Hegde RS

Tue Nov 01 00:00:00 UTC 2022

Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma.

Frontiers in pharmacology

Li R,Yan L,Tian S,Zhao Y,Zhu Y,Wang X

Thu Feb 02 00:00:00 UTC 2023

SEC61G participates in endoplasmic reticulum stress by interacting with CREB3 to promote the malignant progression of lung adenocarcinoma.

Oncology letters

Zhang Q,Guo Z

Fri Jul 01 00:00:00 UTC 2022

Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.

eNeuro

Byts N,Sharma S,Laurila J,Paudel P,Miinalainen I,Ronkainen VP,Hinttala R,Törnquist K,Koivunen P,Myllyharju J

Fri Jun 18 00:00:00 UTC 2021

High SEC61G expression predicts poor prognosis in patients with Head and Neck Squamous Cell Carcinomas.

Journal of Cancer

Liang L,Huang Q,Gan M,Jiang L,Yan H,Lin Z,Zhu H,Wang R,Hu K

Tue Jun 08 00:00:00 UTC 2021

Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.

BMC cancer

Zheng Q,Wang Z,Zhang M,Yu Y,Chen R,Lu T,Liu L,Ma J,Liu T,Zheng H,Li H,Li J

Sat Nov 13 00:00:00 UTC 2021

SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.

Cell death & disease

Ma J,He Z,Zhang H,Zhang W,Gao S,Ni X

Thu May 27 00:00:00 UTC 2021

SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.

Cell death & disease

Ma J,He Z,Zhang H,Zhang W,Gao S,Ni X

Thu May 27 00:00:00 UTC 2021

SEC61G is upregulated and required for tumor progression in human kidney cancer.

Molecular medicine reports

Meng H,Jiang X,Wang J,Sang Z,Guo L,Yin G,Wang Y

Tue Jun 01 00:00:00 UTC 2021

A scalable strategy for high-throughput GFP tagging of endogenous human proteins.

Proceedings of the National Academy of Sciences of the United States of America

Leonetti MD,Sekine S,Kamiyama D,Weissman JS,Huang B

Tue Jun 21 00:00:00 UTC 2016

A scalable strategy for high-throughput GFP tagging of endogenous human proteins.

Proceedings of the National Academy of Sciences of the United States of America

Leonetti MD,Sekine S,Kamiyama D,Weissman JS,Huang B

Tue Jun 21 00:00:00 UTC 2016

The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.

Immunity

Zehner M,Marschall AL,Bos E,Schloetel JG,Kreer C,Fehrenschild D,Limmer A,Ossendorp F,Lang T,Koster AJ,Dübel S,Burgdorf S

Tue May 19 00:00:00 UTC 2015

The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.

Immunity

Zehner M,Marschall AL,Bos E,Schloetel JG,Kreer C,Fehrenschild D,Limmer A,Ossendorp F,Lang T,Koster AJ,Dübel S,Burgdorf S

Tue May 19 00:00:00 UTC 2015

The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.

Neuro-oncology

Johnson GG,White MC,Wu JH,Vallejo M,Grimaldi M

Fri Aug 01 00:00:00 UTC 2014

The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.

Neuro-oncology

Johnson GG,White MC,Wu JH,Vallejo M,Grimaldi M

Fri Aug 01 00:00:00 UTC 2014

The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.

Neuro-oncology

Johnson GG,White MC,Wu JH,Vallejo M,Grimaldi M

Fri Aug 01 00:00:00 UTC 2014

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

eLife

Mackinnon AL,Paavilainen VO,Sharma A,Hegde RS,Taunton J

Tue Nov 24 00:00:00 UTC 2015

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

eLife

Mackinnon AL,Paavilainen VO,Sharma A,Hegde RS,Taunton J

Tue Nov 24 00:00:00 UTC 2015

Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.

Cancer research

Lu Z,Zhou L,Killela P,Rasheed AB,Di C,Poe WE,McLendon RE,Bigner DD,Nicchitta C,Yan H

Tue Dec 01 00:00:00 UTC 2009

Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.

Cancer research

Lu Z,Zhou L,Killela P,Rasheed AB,Di C,Poe WE,McLendon RE,Bigner DD,Nicchitta C,Yan H

Tue Dec 01 00:00:00 UTC 2009

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.

Proceedings of the National Academy of Sciences of the United States of America

Saito K,Dubreuil V,Arai Y,Wilsch-Bräuninger M,Schwudke D,Saher G,Miyata T,Breier G,Thiele C,Shevchenko A,Nave KA,Huttner WB

Tue May 19 00:00:00 UTC 2009

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.

Proceedings of the National Academy of Sciences of the United States of America

Saito K,Dubreuil V,Arai Y,Wilsch-Bräuninger M,Schwudke D,Saher G,Miyata T,Breier G,Thiele C,Shevchenko A,Nave KA,Huttner WB

Tue May 19 00:00:00 UTC 2009

Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer.

The Journal of pathology

Tsukamoto Y,Uchida T,Karnan S,Noguchi T,Nguyen LT,Tanigawa M,Takeuchi I,Matsuura K,Hijiya N,Nakada C,Kishida T,Kawahara K,Ito H,Murakami K,Fujioka T,Seto M,Moriyama M

Mon Dec 01 00:00:00 UTC 2008

Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer.

The Journal of pathology

Tsukamoto Y,Uchida T,Karnan S,Noguchi T,Nguyen LT,Tanigawa M,Takeuchi I,Matsuura K,Hijiya N,Nakada C,Kishida T,Kawahara K,Ito H,Murakami K,Fujioka T,Seto M,Moriyama M

Mon Dec 01 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: protein transport protein SEC61 gamma subunit; Protein transport protein Sec61 subunit gamma; Sec61 gamma subunit

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Gene Aliases: SEC61G; SSS1

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UniProt ID: (Human) P60059, (Mouse) P60060

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Entrez Gene ID: (Human) 23480, (Rat) 689134, (Mouse) 20335

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Function(s)

protein binding protein transporter activity P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function

Process(es)

protein targeting biological_process protein transmembrane transport IRE1-mediated unfolded protein response protein targeting to ER

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SEC61G Polyclonal Antibody

SEC61G Antibody (11147-2-AP) in IHC (P)

Product Details

11147-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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