Proteintech

SELS Polyclonal Antibody

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SELS Antibody (15591-1-AP) in WB

Mouse brain tissue were subjected to SDS PAGE followed by western blot with 15591-1-AP (SELS antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

SELS Antibody in Immunoprecipitation (IP)

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Product Details

15591-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

Assay-dependent

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SELS Fusion Protein Ag7928 (1-189 aa encoded by BC005840)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MERQEESLS ARPALETEGL RFLHTTVGSL LATYGWYIVF SCILLYVVFQ KLSARLRALR QRQLDRAAAA VEPDVVVKRQ EALAAARLKM QEELNAQVEK HKEKLKQLEE EKRRQKIEMW DSMQEGKSYK GNAKKPQEED SPGPSTSSVL KRKSDRKPLR GGGYNPLSGE GGGACSWRPG RRGPSSGGUG (1-189 aa encoded by BC005840)

Target Information

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. It participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes.

Biological trace element research

Wang H,Li Z,Liu Y,Zhang M,Shi Y,Zhang Y,Mi G,Wang M,He Y,Chen Y,Chen C,Chen J

Sat Apr 01 00:00:00 UTC 2023

Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes.

Biological trace element research

Wang H,Li Z,Liu Y,Zhang M,Shi Y,Zhang Y,Mi G,Wang M,He Y,Chen Y,Chen C,Chen J

Sat Apr 01 00:00:00 UTC 2023

Selenoproteins synergistically protect porcine skeletal muscle from oxidative damage via relieving mitochondrial dysfunction and endoplasmic reticulum stress.

Journal of animal science and biotechnology

Jing J,He Y,Liu Y,Tang J,Wang L,Jia G,Liu G,Chen X,Tian G,Cai J,Che L,Kang B,Zhao H

Sun Jun 04 00:00:00 UTC 2023

Reversal of Lipid Metabolism Dysregulation by Selenium and Folic Acid Co-Supplementation to Mitigate Pathology in Alzheimer's Disease.

Antioxidants (Basel, Switzerland)

Zhang ZH,Cao XC,Peng JY,Huang SL,Chen C,Jia SZ,Ni JZ,Song GL

Sun Apr 24 00:00:00 UTC 2022

Selenoprotein K Is Essential for the Migration and Phagocytosis of Immature Dendritic Cells.

Antioxidants (Basel, Switzerland)

Xia H,Wang Y,Dai J,Zhang X,Zhou J,Zeng Z,Jia Y

Mon Jun 27 00:00:00 UTC 2022

Quantitative proteomics reveals potential anti-inflammatory protein targets of radial extracorporeal shock wave therapy in TNF-α-induced model of acute inflammation in primary human tenocytes.

Heliyon

Ge R,Zhu Q,Liu D,Zhang Q,Jiang S,Yu X,Shu J,Gao F,Guo J,Chen S,Gao B

Thu Dec 01 00:00:00 UTC 2022

Hydroxy Selenomethionine Alleviates Hepatic Lipid Metabolism Disorder of Pigs Induced by Dietary Oxidative Stress via Relieving the Endoplasmic Reticulum Stress.

Antioxidants (Basel, Switzerland)

Jing J,Yin S,Liu Y,Liu Y,Wang L,Tang J,Jia G,Liu G,Tian G,Chen X,Cai J,Kang B,Zhao H

Tue Mar 15 00:00:00 UTC 2022

Selenium exerts protective effects against heat stress-induced barrier disruption and inflammation response in jejunum of growing pigs.

Journal of the science of food and agriculture

He Y,Liu Y,Tang J,Jia G,Liu G,Tian G,Chen X,Cai J,Kang B,Zhao H

Sun Jan 30 00:00:00 UTC 2022

Sodium selenite attenuates zearalenone-induced apoptosis through inhibition of endoplasmic reticulum stress in goat trophoblast cells.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Xiong Y,Li B,Li J,Jin E,He S

Mon Aug 01 00:00:00 UTC 2022

Transcriptomic analysis reveals the effects of maternal selenium deficiency on placental transport, hormone synthesis, and immune response in mice.

Metallomics : integrated biometal science

Cheng W,Zhang L,Sa P,Luo J,Li M

Mon Sep 12 00:00:00 UTC 2022

Comprehensive Analysis of Expression and Prognostic Value of Selenoprotein Genes in Thyroid Cancer.

Genetic testing and molecular biomarkers

Zhao Y,Chen P,Lv HJ,Wu Y,Liu S,Deng X,Shi B,Fu J

Fri Apr 01 00:00:00 UTC 2022

Dietary selenium sources differentially regulate selenium concentration, mRNA and protein expression of representative selenoproteins in various tissues of yellow catfish Pelteobagrus fulvidraco.

The British journal of nutrition

Xu XJ,Zhang DG,Zhao T,Xu YH,Luo Z

Mon Feb 28 00:00:00 UTC 2022

Maternal Organic Selenium Supplementation Relieves Intestinal Endoplasmic Reticulum Stress in Piglets by Enhancing the Expression of Glutathione Peroxidase 4 and Selenoprotein S.

Frontiers in nutrition

Ding D,Mou D,Zhu H,Jiang X,Che L,Fang Z,Xu S,Lin Y,Zhuo Y,Li J,Huang C,Zou Y,Li L,Wu D,Feng B

Tue May 24 00:00:00 UTC 2022

Selenoprotein S attenuates high glucose and/or ox-LDL-induced endothelium injury by regulating Akt/mTOR signaling and autophagy.

The international journal of biochemistry & cell biology

Wang Z,Li Y,Yao J,Yu S,Yu H,Men L,Du J

Wed Dec 01 00:00:00 UTC 2021

Hydroxy Selenomethionine Improves Meat Quality through Optimal Skeletal Metabolism and Functions of Selenoproteins of Pigs under Chronic Heat Stress.

Antioxidants (Basel, Switzerland)

Liu Y,Yin S,Tang J,Liu Y,Jia G,Liu G,Tian G,Chen X,Cai J,Kang B,Zhao H

Wed Sep 29 00:00:00 UTC 2021

Dietary Marginal and Excess Selenium Increased Triglycerides Deposition, Induced Endoplasmic Reticulum Stress and Differentially Influenced Selenoproteins Expression in the Anterior and Middle Intestines of Yellow Catfish Pelteobagrus fulvidraco.

Antioxidants (Basel, Switzerland)

Zhang DG,Zhao T,Xu XJ,Lv WH,Luo Z

Mon Mar 29 00:00:00 UTC 2021

Selenogenome and AMPK signal insight into the protective effect of dietary selenium on chronic heat stress-induced hepatic metabolic disorder in growing pigs.

Journal of animal science and biotechnology

Liu Y,Tang J,He Y,Jia G,Liu G,Tian G,Chen X,Cai J,Kang B,Zhao H

Sat Jun 12 00:00:00 UTC 2021

Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.

Frontiers in microbiology

Zhuang C,Liu G,Barkema HW,Zhou M,Xu S,Ur Rahman S,Liu Y,Kastelic JP,Gao J,Han B

Mon Sep 28 00:00:00 UTC 2020

Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.

Journal of cellular and molecular medicine

Min Z,Guo Y,Sun M,Hussain S,Zhao Y,Guo D,Huang H,Heng L,Zhang F,Ning Q,Han Y,Xu P,Zhong N,Sun J,Lu S

Sat Dec 01 00:00:00 UTC 2018

Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.

Journal of cellular and molecular medicine

Min Z,Guo Y,Sun M,Hussain S,Zhao Y,Guo D,Huang H,Heng L,Zhang F,Ning Q,Han Y,Xu P,Zhong N,Sun J,Lu S

Sat Dec 01 00:00:00 UTC 2018

Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.

Journal of cellular and molecular medicine

Min Z,Guo Y,Sun M,Hussain S,Zhao Y,Guo D,Huang H,Heng L,Zhang F,Ning Q,Han Y,Xu P,Zhong N,Sun J,Lu S

Sat Dec 01 00:00:00 UTC 2018

Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage.

Journal of cellular and molecular medicine

Min Z,Guo Y,Sun M,Hussain S,Zhao Y,Guo D,Huang H,Heng L,Zhang F,Ning Q,Han Y,Xu P,Zhong N,Sun J,Lu S

Sat Dec 01 00:00:00 UTC 2018

Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

Biochemical and biophysical research communications

Men L,Yu S,Yao J,Li Y,Ren D,Du J

Tue Sep 18 00:00:00 UTC 2018

Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

Biochemical and biophysical research communications

Men L,Yu S,Yao J,Li Y,Ren D,Du J

Tue Sep 18 00:00:00 UTC 2018

Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

Biochemical and biophysical research communications

Men L,Yu S,Yao J,Li Y,Ren D,Du J

Tue Sep 18 00:00:00 UTC 2018

Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.

Biochemical and biophysical research communications

Men L,Yu S,Yao J,Li Y,Ren D,Du J

Tue Sep 18 00:00:00 UTC 2018

Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Men L,Sun J,Ren D

Fri Jan 25 00:00:00 UTC 2019

Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Men L,Sun J,Ren D

Fri Jan 25 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: histocompatibility 47; MGC104346; MGC2553; Minor histocompatibility antigen H47; Selenoprotein S; SelS; Sg2; Tanis; valosin-containing protein-interacting membrane protein; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein

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Gene Aliases: 1500011E07Rik; AD-015; ADO15; C78786; H-4; H-47; H4; H47; SBBI8; SELENOS; SELS; SEPS1; sg2; VIMP

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UniProt ID: (Human) Q9BQE4, (Rat) Q8VHV8, (Mouse) Q9BCZ4

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Entrez Gene ID: (Human) 55829, (Rat) 286900, (Mouse) 109815

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Function(s)

receptor activity protein binding antioxidant activity enzyme binding ATPase binding ubiquitin-specific protease binding selenium binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SELS Polyclonal Antibody

SELS Antibody (15591-1-AP) in WB

Product Details

15591-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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