Invitrogen

SEMA3A Polyclonal Antibody

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View all (17) SEMA3A antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-67972

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human SEMA3A.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2691930

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: collapsin 1; collapsin-1; MGC133243; Sema D; sema domain, immunoglobulin domain (Ig), short basic domain, sec; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Sema III; Semaphorin 3a; semaphorin D; Semaphorin III; semaphorin L; Semaphorin-3A; Semaphorin-D

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Gene Aliases: coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMA3A; SEMAD; SEMAIII; SEMAL; SemD

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UniProt ID: (Human) Q14563, (Mouse) O08665, (Rat) Q63548

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Entrez Gene ID: (Human) 10371, (Mouse) 20346, (Rat) 29751

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Function(s)
semaphorin receptor binding neuropilin binding chemorepellent activity receptor activity
Process(es)
neural crest cell migration neuron migration regulation of heart rate apoptotic process axon guidance axonal fasciculation negative regulation of epithelial cell migration facial nerve structural organization trigeminal nerve structural organization nerve development olfactory bulb development branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus ventral trunk neural crest cell migration sympathetic nervous system development dendrite morphogenesis regulation of axon extension involved in axon guidance negative regulation of axon extension involved in axon guidance axon extension involved in axon guidance sensory system development negative chemotaxis axonogenesis involved in innervation dichotomous subdivision of terminal units involved in salivary gland branching sympathetic ganglion development trigeminal ganglion development semaphorin-plexin signaling pathway sympathetic neuron projection extension sympathetic neuron projection guidance neural crest cell migration involved in autonomic nervous system development semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance neural crest cell migration involved in sympathetic nervous system development facioacoustic ganglion development positive regulation of male gonad development positive regulation of neuron migration multicellular organism development nervous system development motor neuron axon guidance cell differentiation negative regulation of axon extension
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