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Invitrogen
SEMA3B Polyclonal Antibody
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SEMA3B Antibody (PA1-16932) in IHC (P)
Immunohistochemical analysis of SEMA3B in formalin fixed paraffin embedded tissue section of mouse kidney. Samples were incubated in SEMA3B polyclonal antibody (Product # PA1-16932) using a dilution of 1:200. This antibody generated a weak to moderate cytoplasmic staining in the cells of various renal tubules and glomeruli.
Product Details
PA1-16932
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide between amino acids 100-200 of the human SEMA 3B protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2185418
Product Specific Information
In Western Blot, a band is seen at ~50 kDa, representing the secreted form of the protein and also a faint band at ~83 kDa, representing the pro-form of the protein.
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Suggested positive control: antigen standard for SEMA3B (transient overexpression lysate), mouse Cerebellum protein, mouse E16 cerebellum lysate.
Target Information
The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Seam V antibody; sema A; Sema A(V); sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Sema V; semaphorin A; Semaphorin-3B; semaphorin-A; Semaphorin-V
Gene Aliases: BOS_21064; LUCA-1; SemA; SEMA3B; SEMA5; SEMAA; semaV
UniProt ID: (Human) Q13214
Entrez Gene ID: (Human) 7869, (Bovine) 539996, (Dog) 484762, (Mouse) 20347, (Rat) 363142
neural crest cell migration
cell-cell signaling
axon guidance
positive regulation of cell migration
negative regulation of axon extension involved in axon guidance
negative chemotaxis
semaphorin-plexin signaling pathway
multicellular organism development
nervous system development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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