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Invitrogen
SEMA6A Polyclonal Antibody
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Product Details
PA5-143761
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Semaphorin 6A synthetic peptide (coupled to carrier protein) corresponding to amino acids in the cytoplasmic region of human Sema-6A. The sequence used has high homology to similar regions in rat and mouse Sema-6A, and has low homology to other semaphorin family members.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2942989
Product Specific Information
The antibody detects a 120kDa* protein corresponding to the apparent molecular mass of Sema-6A on SDS-PAGE immunoblots of Sema-6A transfected COS7 cells, human colorectal cancer cells, and rat PC12 cells. In addition, shRNA knockdown of Sema-6A expression significantly reduces detection of Sema-6A using anti-Sema-6A (a.a. 772-787) antibody.
Target Information
SEMA6A can act as repulsive axon guidance cues. It may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mutant line 997; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; Sema Q; Sema VIA; SEMA6A-1; semaphorin 6A-1; Semaphorin Q; Semaphorin VIA; Semaphorin-6A; Semaphorin-6A-1
Gene Aliases: 9330158E07; A730020P05Rik; AI851735; b2b997Clo; HT018; KIAA1368; SEMA; SEMA6A; Sema6A-1; SEMA6A1; SEMAQ; VIA
UniProt ID: (Human) Q9H2E6, (Mouse) O35464
Entrez Gene ID: (Human) 57556, (Rat) 361324, (Mouse) 20358
neural crest cell migration
apoptotic process
cytoskeleton organization
cell surface receptor signaling pathway
nervous system development
axon guidance
organ morphogenesis
negative regulation of axon extension involved in axon guidance
negative chemotaxis
semaphorin-plexin signaling pathway
positive regulation of neuron migration
neuron migration
multicellular organism development
centrosome localization
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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