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Product Details
MA1-19203
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
MEM-150
Immunogen
T cell line HPB-ALL.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
TBS, pH 8
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1071134
Product Specific Information
This antibody reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored extracellular glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.
Western Blot: non-reducing conditions.
Target Information
CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors - plexin C1 and beta1 integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD108; CDw108; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; John-Milton-Hargen human blood group Ag; MGC126692; MGC126696; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Semaphorin-7A; Semaphorin-K1; Semaphorin-L
Gene Aliases: CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMA7A; SEMAK1; SEMAL
UniProt ID: (Human) O75326
Entrez Gene ID: (Human) 8482
osteoblast differentiation
neural crest cell migration
inflammatory response
immune response
integrin-mediated signaling pathway
olfactory lobe development
positive regulation of cell migration
positive regulation of axon extension
axon extension
negative regulation of axon extension involved in axon guidance
regulation of inflammatory response
negative chemotaxis
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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