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OriGene
SENP2 Monoclonal Antibody (OTI3E7), TrueMAB™
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Product Details
CF800127
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3E7
Immunogen
Human recombinant protein fragment corresponding to amino acids 139-523 of human SENP2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
SUMO is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1, SUMO2, and SUMO3 into the conjugatable mature forms and catalyze the deconjugation of these same SUMO proteins from their targeted substrates. SENP2 may also down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axam2; CT; Sentrin-specific protease 2; Sentrin/SUMO-specific protease SENP2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO1/sentrin/SMT3 specific protease 2
Gene Aliases: AXAM2; KIAA1331; SENP2; SMT3IP2
UniProt ID: (Human) Q9HC62
Entrez Gene ID: (Human) 59343
positive regulation of protein phosphorylation
heart development
dorsal/ventral axis specification
protein transport
Wnt signaling pathway
protein sumoylation
protein desumoylation
regulation of Wnt signaling pathway
negative regulation of protein ubiquitination
positive regulation of protein ubiquitination
protein destabilization
negative regulation of protein binding
regulation of DNA endoreduplication
negative regulation of chromatin binding
negative regulation of DNA damage response, signal transduction by p53 class mediator
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA transport
trophoblast giant cell differentiation
labyrinthine layer development
spongiotrophoblast layer development
regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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