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Invitrogen
SENP6 Polyclonal Antibody
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Product Details
PA5-75186
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 1040-1089 of Human SENP6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718914
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Ubiquitin-like molecules, such as SUMO1, are structurally related to ubiquitin. and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1. to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2810017C20Rik; FLJ11355; FLJ11887; KIAA0389; RP1-134M13.1; Sentrin-specific protease 6; Sentrin/SUMO-specific protease SENP6; SUMO-1-specific protease 1; SUMO/sentrin specific peptidase 6; SUMO/sentrin specific protease 6; SUMO1/sentrin specific protease 6; Sumo1/sentrin/SMT3 specific peptidase 6
Gene Aliases: FKSG6; KIAA0797; SENP6; SSP1; SUSP1
UniProt ID: (Human) Q9GZR1
Entrez Gene ID: (Human) 26054, (Rat) 300860
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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