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Product Details
12476-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SEPT4 Fusion Protein Ag3185 (113-459 aa encoded by BC018056)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY (113-459 aa encoded by BC018056)
Target Information
Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 4-Sep; apoptosis-related protein in the TGF-beta signaling pathway; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; cell division control-related protein 2b; cerebral protein 7; expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; hCDCREL-2; M-Septin; peanut-like 2; peanut-like 2 homolog; Peanut-like protein 2; septin H5; Septin-4; septin-M
Gene Aliases: ARTS; Bh5; BRADEION; C17orf47; CE5B3; EG3-1RVC; EG3RVC; Gm11492; H5; hCDCREL-2; hucep-7; MART; OTTMUSG00000001265; PNUTL2; SEP4; SEPT4; SEPTIN4
UniProt ID: (Human) O43236, (Mouse) P28661
Entrez Gene ID: (Human) 5414, (Mouse) 18952, (Rat) 287606
apoptotic process
cell cycle
brain development
sperm mitochondrion organization
positive regulation of protein ubiquitination
regulation of apoptotic process
positive regulation of apoptotic process
sperm capacitation
cell division
positive regulation of intrinsic apoptotic signaling pathway
spermatid development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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