Proteintech

SEPT8 Polyclonal Antibody

SEPT8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SEPT8 Antibody (11769-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 11769-1-AP (SEPT8 antibody) at dilution of 1:100 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SEPT8 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11769-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SEPT8 Fusion Protein Ag2357 (1-256 aa encoded by BC001329)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKKLDSKVN IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP LRKDKDK (1-256 aa encoded by BC001329)

Target Information

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking (Blaser et al., 2003 [PubMed 12909369]).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice.

Cytoskeleton (Hoboken, N.J.)

Martens AK,Erwig M,Patzig J,Fledrich R,Füchtbauer EM,Werner HB

Tue Sep 19 00:00:00 UTC 2023

Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice.

Cytoskeleton (Hoboken, N.J.)

Martens AK,Erwig M,Patzig J,Fledrich R,Füchtbauer EM,Werner HB

Tue Sep 19 00:00:00 UTC 2023

Pinch2 regulates myelination in the mouse central nervous system.

Development (Cambridge, England)

Paes de Faria J,Vale-Silva RS,Fässler R,Werner HB,Relvas JB

Fri Jul 01 00:00:00 UTC 2022

Abnormal Spinal Cord Myelination due to Oligodendrocyte Dysfunction in a Model of Huntington's Disease.

Journal of Huntington's disease

Ferrari Bardile C,Sidik H,Quek R,Yusof NABM,Garcia-Miralles M,Pouladi MA

Thu Jan 13 00:00:00 UTC 2022

Impaired Platelet Function in Sept8-Deficient Mice In Vitro.

Thrombosis and haemostasis

Neubauer K,Jurk K,Petermann V,Kumm E,Zieger B

Thu Apr 01 00:00:00 UTC 2021

Impaired Platelet Function in Sept8-Deficient Mice In Vitro.

Thrombosis and haemostasis

Neubauer K,Jurk K,Petermann V,Kumm E,Zieger B

Thu Apr 01 00:00:00 UTC 2021

The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.

Glia

Jarjour AA,Velichkova AN,Boyd A,Lord KM,Torsney C,Henderson DJ,Ffrench-Constant C

Tue Sep 01 00:00:00 UTC 2020

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.

eLife

Erwig MS,Patzig J,Steyer AM,Dibaj P,Heilmann M,Heilmann I,Jung RB,Kusch K,Möbius W,Jahn O,Nave KA,Werner HB

Wed Jan 23 00:00:00 UTC 2019

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.

eLife

Erwig MS,Patzig J,Steyer AM,Dibaj P,Heilmann M,Heilmann I,Jung RB,Kusch K,Möbius W,Jahn O,Nave KA,Werner HB

Wed Jan 23 00:00:00 UTC 2019

Characterization of septin expression in normal and fibrotic kidneys.

Cytoskeleton (Hoboken, N.J.)

Neubauer K,Neubauer B,Seidl M,Zieger B

Tue Jan 01 00:00:00 UTC 2019

Characterization of septin expression in normal and fibrotic kidneys.

Cytoskeleton (Hoboken, N.J.)

Neubauer K,Neubauer B,Seidl M,Zieger B

Tue Jan 01 00:00:00 UTC 2019

A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling.

Cells

Sun L,Cao X,Lechuga S,Feygin A,Naydenov NG,Ivanov AI

Sun Dec 29 00:00:00 UTC 2019

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

Journal of cell science

Kurkinen KM,Marttinen M,Turner L,Natunen T,Mäkinen P,Haapalinna F,Sarajärvi T,Gabbouj S,Kurki M,Paananen J,Koivisto AM,Rauramaa T,Leinonen V,Tanila H,Soininen H,Lucas FR,Haapasalo A,Hiltunen M

Wed Jun 01 00:00:00 UTC 2016

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

Journal of cell science

Kurkinen KM,Marttinen M,Turner L,Natunen T,Mäkinen P,Haapalinna F,Sarajärvi T,Gabbouj S,Kurki M,Paananen J,Koivisto AM,Rauramaa T,Leinonen V,Tanila H,Soininen H,Lucas FR,Haapasalo A,Hiltunen M

Wed Jun 01 00:00:00 UTC 2016

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

Journal of cell science

Kurkinen KM,Marttinen M,Turner L,Natunen T,Mäkinen P,Haapalinna F,Sarajärvi T,Gabbouj S,Kurki M,Paananen J,Koivisto AM,Rauramaa T,Leinonen V,Tanila H,Soininen H,Lucas FR,Haapasalo A,Hiltunen M

Wed Jun 01 00:00:00 UTC 2016

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

eLife

Patzig J,Erwig MS,Tenzer S,Kusch K,Dibaj P,Möbius W,Goebbels S,Schaeren-Wiemers N,Nave KA,Werner HB

Tue Aug 09 00:00:00 UTC 2016

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

eLife

Patzig J,Erwig MS,Tenzer S,Kusch K,Dibaj P,Möbius W,Goebbels S,Schaeren-Wiemers N,Nave KA,Werner HB

Tue Aug 09 00:00:00 UTC 2016

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

eLife

Patzig J,Erwig MS,Tenzer S,Kusch K,Dibaj P,Möbius W,Goebbels S,Schaeren-Wiemers N,Nave KA,Werner HB

Tue Aug 09 00:00:00 UTC 2016

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

eLife

Patzig J,Erwig MS,Tenzer S,Kusch K,Dibaj P,Möbius W,Goebbels S,Schaeren-Wiemers N,Nave KA,Werner HB

Tue Aug 09 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 2-Sep; sept8 {ECO:0000312|EMBL:AAI58797.1, ECO:0000312|RGD:1308449}; Septin-8; septin-8 {ECO:0000250|UniProtKB:Q8CHH9}

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Gene Aliases: AW046166; KIAA0202; mKIAA0202; SEP2; Sepl; SEPT8; SEPTIN8

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UniProt ID: (Human) Q92599, (Mouse) Q8CHH9

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Entrez Gene ID: (Human) 23176, (Rat) 303135, (Mouse) 20362

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Function(s)

protein binding GTP binding nucleotide binding molecular_function

Process(es)

biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SEPT8 Polyclonal Antibody

SEPT8 Antibody (11769-1-AP) in IHC (P)

Product Details

11769-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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