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Invitrogen
SERCA1 ATPase Recombinant Rabbit Monoclonal Antibody (2T8S3)
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Product Details
MA5-37935
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2T8S3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 900-1001 of human SERCA1/ATP2A1 (O14983)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897855
Product Specific Information
Positive Samples: Mouse skeletal muscle
Immunogen sequence: ALSVLVTIEM CNALNSLSEN QSLLRMPPWV NIWLLGSICL SMSLHFLILY VDPLPMIFKL RALDLTQWLM VLKISLPVIG LDEILKFVAR NYLEDPEDER RK
Target Information
ATP dependent calcium pumps are responsible, in part, for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA1 gene is exclusively expressed in type II (fast) skeletal muscle. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific form expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA; SERCA ATPase; SERCA1; SR Ca(2+)-ATPase 1
Gene Aliases: Atp2a1; SERCA1
UniProt ID: (Mouse) Q8R429, (Rat) Q64578
Entrez Gene ID: (Mouse) 11937, (Rat) 116601
transport
ion transport
calcium ion transport
regulation of muscle contraction
regulation of striated muscle contraction
apoptotic mitochondrial changes
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of endoplasmic reticulum calcium ion concentration
negative regulation of endoplasmic reticulum calcium ion concentration
response to endoplasmic reticulum stress
response to peptide hormone
negative regulation of striated muscle contraction
positive regulation of mitochondrial calcium ion concentration
maintenance of mitochondrion location
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
sarcoplasmic reticulum calcium ion transport
calcium ion import
calcium ion transmembrane transport
relaxation of skeletal muscle
carbohydrate derivative transport
nucleotide transmembrane transport
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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