Invitrogen

SERCA2 ATPase Recombinant Rabbit Monoclonal Antibody (10F0M9)

View all (21) SERCA2 ATPase antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35155

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10F0M9

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 943-1042 of human SERCA2/ATP2A2 (P16615)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.62 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849060

Product Specific Information

Immunogen sequence: HFLILYVEPL PLIFQITPLN VTQWLMVLKI SLPVILMDET LKFVARNYLE PGKECVQPAT KSCSFSACTD GISWPFVLLI MPLVIWVYST DTNFSDMFWS

Target Information

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA; SERCA ATPase; SERCA2; SR Ca(2+)-ATPase 2

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Gene Aliases: 9530097L16Rik; ATP2A2; ATP2B; D5Wsu150e; DAR; DD; mKIAA4195; SERCA2; Serca2a; SERCA2B; SercaII

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UniProt ID: (Human) P16615, (Mouse) O55143, (Rat) P11507

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Entrez Gene ID: (Human) 488, (Mouse) 11938, (Rat) 29693

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Function(s)
calcium-transporting ATPase activity calcium ion binding protein binding ATP binding protein C-terminus binding enzyme binding lutropin-choriogonadotropic hormone receptor binding S100 protein binding calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential nucleotide binding hydrolase activity metal ion binding
Process(es)
regulation of the force of heart contraction ER-nucleus signaling pathway organelle organization cell adhesion epidermis development positive regulation of heart rate regulation of cardiac muscle contraction by calcium ion signaling transition between fast and slow fiber endoplasmic reticulum calcium ion homeostasis positive regulation of endoplasmic reticulum calcium ion concentration T-tubule organization ion transmembrane transport cellular response to oxidative stress response to endoplasmic reticulum stress response to peptide hormone negative regulation of heart contraction relaxation of cardiac muscle sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of calcium ion-dependent exocytosis of neurotransmitter calcium ion transport from cytosol to endoplasmic reticulum regulation of cardiac conduction calcium ion import into sarcoplasmic reticulum transport ion transport calcium ion transport cellular calcium ion homeostasis regulation of muscle contraction metabolic process
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