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Immunogen sequence: TRRMARKNAI VRSLPSVETL GCTSVICSDK TGTLTTNQMS VCRMFVVAEA DAGSCLLHEF TISGTTYTPE GEVRQGDQPV RCGQFDGLVE LATICALCND SALDYNEAKG VYEKVGEATE TALTCLVEKM NVFDTDLQAL SRVERAGACN TVIKQLMRKE FTLEFSRDRK SMSVYCTPTR PHPTGQGSKM FVKGAPESVI ERCSSVRVGS RTAPLTPTSR EQILAKIRDW GSGSDTLRCL ALATRDAPPR KEDMELDDCS KFVQYETDLT FVGCVGMLDP PRPEVAACIT RCYQAGIRVV MITGDNKGTA VAICRRLGIF GDTEDVAGKA YTGREFDDLS PEQQRQACRT ARCFARVEPA HKSRIVENLQ SFNEITAMTG DGVNDAPALK KAEIGIAMGS GTAVAKSAAE MVLSDDNFAS IVAAVEEGRA IYSNMKQFIR YLISSNVGEV VCIFLTAILG LPEALIPVQL LWVNLVTDGL PATALGFNPP DLDIMEKLPR SPREALISGW LFFRYLAIGV YVGLATVAAA TWWFVYDAEG PHINFYQLRN FLKCSEDNPL FAGIDCEVFE SRFPTTMALS VLVTIEMCNA LNSVSENQSL LRMPPWMNPW LLVAVAMSMA LHFLILLVPP LPLIFQVTPL SGRQWVVVLQ ISLPVILLDE ALKYLSRNHM HEEMSQK
ATP dependent calcium pumps are responsible in part for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium ATPases (SERCA). The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific isoform expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. SERCA3 has been found to co-express with SERCA2b in platelets, mast cells, lymphoid cells, and epithelial cells. Due to this pattern of expression it is referred to as the non-muscle form of SERCA.
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Protein Aliases: adenosine triphosphatase, calcium; ATPase, Ca(2+)-transporting, ubiquitous; ATPase, Ca++ transporting, ubiquitous; Calcium pump 3; calcium-translocating P-type ATPase; sarco/endoplasmic reticulum Ca2+ -ATPase; sarcoendoplasmic reticulum Ca2+ ATPase type 3; Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; SR Ca(2+)-ATPase 3
Gene Aliases: ATP2A3; SERCA3; SERCA3b
UniProt ID: (Human) Q93084, (Rat) P18596, (Mouse) Q64518
Entrez Gene ID: (Human) 489, (Rat) 25391, (Mouse) 53313
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