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Proteintech
SERINC3 Polyclonal Antibody
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Product Details
20267-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to SERINC3.
Target Information
TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIGP-1; Axotomy-induced glyco/Golgi protein 1; Axotomy-induced glycoprotein 1; Membrane protein TMS-1; Serine incorporator 3; tumor differentially expressed 1; Tumor differentially expressed protein 1
Gene Aliases: AA959945; AA960047; AIGP1; DIFF33; SBBI99; SERINC3; TDE; TDE1; TMS-1; Tms1
UniProt ID: (Human) Q13530, (Mouse) Q9QZI9
Entrez Gene ID: (Human) 10955, (Mouse) 26943, (Rat) 296350
phosphatidylserine metabolic process
sphingolipid metabolic process
L-serine transport
cation transmembrane transport
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
L-alpha-amino acid transmembrane transport
positive regulation of transferase activity
detection of virus
innate immune response
defense response to virus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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