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SERPINF1 Antibody (TA504434) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINF1 (RC204186, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SER. Positive lysates LY400927 (100 µg) and LC400927 (20 µg) can be purchased separately from OriGene.
Product Details
TA504434
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI1F7
Immunogen
Full length human recombinant protein of human SERPINF1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1.08 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; PEDF; PIG 35; Pigment epithelium-derived factor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF 1; sserpin family F member 1; testis tissue sperm-binding protein Li 70n
Gene Aliases: EPC-1; OI12; OI6; PEDF; PIG35; SERPINF1
UniProt ID: (Human) P36955
Entrez Gene ID: (Human) 5176
kidney development
multicellular organism development
aging
short-term memory
cell proliferation
response to acidic pH
negative regulation of endothelial cell migration
negative regulation of gene expression
negative regulation of endopeptidase activity
positive regulation of neuron projection development
negative regulation of angiogenesis
ovulation cycle
response to arsenic-containing substance
negative regulation of inflammatory response
positive regulation of neurogenesis
retina development in camera-type eye
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to cobalt ion
cellular response to retinoic acid
cellular response to glucose stimulus
cellular response to dexamethasone stimulus
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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