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Invitrogen
SESN1 Recombinant Rabbit Monoclonal Antibody (7I5Y4)
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FIGURE: 1 / 3
SESN1 Antibody (MA5-38000) in IHC (P)
Immunohistochemistry analysis of SESN1 in paraffin-embedded human colon carcinoma. Samples were incubated with SESN1 Monoclonal antibody (Product # MA5-38000) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-38000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7I5Y4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human sestrin 1 (Q9Y6P5)
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897918
Product Specific Information
Positive Samples: HepG2, PC-3
Immunogen sequence: KTQHYLLQMD GPLPLHYRHY IGIMAAARHQ CSYLVNLHVN DFLHVGGDPK WLNGLENAPQ KLQNLGELNK VLAHRPWLIT KEHIEGLLKA EEHSWSLAEL V
Target Information
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; Sestrin-1
Gene Aliases: 1110002G11Rik; AU044290; PA26; SESN1; SEST1
UniProt ID: (Human) Q9Y6P5, (Mouse) P58006
Entrez Gene ID: (Human) 27244, (Mouse) 140742
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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