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Invitrogen
SET Polyclonal Antibody
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FIGURE: 1 / 7
SET Antibody (PA5-78163) in ICC/IF
SET Polyclonal Antibody detects SET protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SET protein stained by SET Polyclonal Antibody (Product # PA5-78163) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin Polyclonal Antibody [GT114] (Product # MA5-31466) diluted at 1:1,000. Blue: Hoechst 33342 staining.
Product Details
PA5-78163
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SET. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736583
Product Specific Information
Positive Control: A431, H1299, HeLa, HepG2, Molt-4, Raji, Neuro 2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2, C2C12
Predicted Reactivity: Xenopus laevis (99%), Pig (100%), Chicken (100%), Bovine (99%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SET is a multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HLA-DR-associated protein II; I IGAAD; I-2PP2A; IGAAD; Inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; Liver regeneration-related protein LRRGR00002; OTTHUMP00000022286; PHAPII; Phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; Protein SET; RP11-216B9.3; SET nuclear oncogene; SET translocation; SET translocation (myeloid leukemia-associated); TAF-1a; TAF-1b; TAF-I; Template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor
Gene Aliases: 2610030F17Rik; 2PP2A; 5730420M11Rik; AA407739; Ab1-115; I-2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; SET; StF-IT-1; TAF-I; TAF-IBETA
UniProt ID: (Human) Q01105, (Mouse) Q9EQU5, (Rat) Q63945
Entrez Gene ID: (Human) 6418, (Mouse) 56086, (Rat) 307947
nucleosome assembly
negative regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
DNA replication
nucleosome disassembly
nucleocytoplasmic transport
viral process
regulation of protein phosphatase type 2A activity
negative regulation of histone acetylation
negative regulation of catalytic activity
regulation of mRNA stability
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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