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Proteintech
SETMAR Polyclonal Antibody
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Product Details
25814-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SETMAR Fusion Protein Ag22938 (322-671 aa encoded by BC008931)
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KRLTLETMK MMLDKKQIRA IFLFEFKMGR KAAETTRNIN NAFGPGTANE RTVQWWFKKF CKGDESLEDE ERSGRPSEVD NDQLRAIIEA DPLTTTREVA EELNVNHSTV VRHLKQIGKV KKLDKWVPHE LTENQKNRRF EVSSSLILRN HNEPFLDRIV TCDEKWILYD NRRRSAQWLD QEEAPKHFPK PILHPKKVMV TIWWSAAGLI HYSFLNPGET ITSEKYAQEI DEMNQKLQRL QLALVNRKGP ILLHDNARPH VAQPTLQKLN ELGYEVLPHP PYSPDLLPTN YHVFKHLNNF LQGKRFHNQQ DAENAFQEFV ESQSTDFYAT GINQLISRWQ KCVDCNGSYF D (322-671 aa encoded by BC008931)
Target Information
SETMAR (SET domain and mariner transposase fusion gene) is a histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, creating specific tags for epigenetic transcriptional activation. It specifically mediates dimethylation of H3 Lys-36. SETMAR has sequence-specific DNA-binding activity, and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 transposable element. SETMAT has DNA nicking activity, and in vivo end-joining activity, and may mediate genomic integration of foreign DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase SETMAR; Metnase; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein
Gene Aliases: Mar1; METNASE; SETMAR
UniProt ID: (Human) Q53H47
Entrez Gene ID: (Human) 6419
single-stranded DNA endodeoxyribonuclease activity
double-stranded DNA binding
single-stranded DNA binding
endonuclease activity
protein binding
zinc ion binding
histone methyltransferase activity (H3-K4 specific)
protein homodimerization activity
structure-specific DNA binding
DNA topoisomerase binding
histone methyltransferase activity (H3-K36 specific)
DNA double-strand break processing
DNA catabolic process, endonucleolytic
double-strand break repair via nonhomologous end joining
cell proliferation
histone H3-K36 methylation
DNA integration
replication fork processing
mitotic DNA integrity checkpoint
histone H3-K4 methylation
negative regulation of cell cycle arrest
nucleic acid phosphodiester bond hydrolysis
histone H3-K36 dimethylation
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
positive regulation of double-strand break repair via nonhomologous end joining
negative regulation of chromosome organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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