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Invitrogen
SF3B2 Polyclonal Antibody
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Product Details
PA5-96456
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 616-895 of human SF3B2 (NP_0068332)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808258
Product Specific Information
Immunogen sequence: SLGMPVGPNA HKVPPPWLIA MQRYGPPPSY PNLKIPGLNS PIPESCSFGY HAGGWGKPPV DETGKPLYGD VFGTNAAEFQ TKTEEEEIDR TPWGELEPSD EESSEEEEEE ESDEDKPDET GFITPADSGL ITPGGFSSVP AGMETPELIE LRKKKIEEAM DGSETPQLFT VLPEKRTATV GGAMMGSTHI YDMSTVMSRK GPAPELQGVE VALAPEELEL DPMAMTQKYE EHVREQQAQV EKEDFSDMVA EHAAKQKQKK RKAQPQDSRG GSKKYKEFKF; Positive Samples: HeLa, MCF7, SW620, A375, Mouse testis; Cellular Location: Nucleus
Target Information
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pre-mRNA splicing factor SF3b 145 kDa subunit; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SAP 145; SF3b145; spliceosome associated protein 145; Spliceosome-associated protein 145; Splicing factor 3B subunit 2; splicing factor 3b, subunit 2, 145kD; splicing factor 3b, subunit 2, 145kDa
Gene Aliases: 145kDa; 2610311M13Rik; 2810441F20Rik; B230398H18Rik; Cus1; SAP145; SF3b1; SF3B145; SF3b150; SF3B2
UniProt ID: (Human) Q13435, (Mouse) Q3UJB0
Entrez Gene ID: (Human) 10992, (Rat) 293671, (Mouse) 319322
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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