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Product Details
PA1-4138
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues A(25) P A R C E E Y D Y Y G W Q(38) of human SFRP5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2187200
Product Specific Information
PA1-4138 detects human SFRP5.
PA1-4138 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~40 kDa protein representing human SFRP5 in pancreas lysate.
The PA1-4138 immunogen is a synthetic peptide corresponding to residues A(25) P A R C E E Y D Y Y G W Q(38) of human SFRP5. This sequence is 92% conserved in bovine, 82% conserved in rat, and 78% conserved in mouse.
Maintain at 4ºC for 3 months or at -20ºC for longer periods. Stable for 1 year. Avoid freeze/thaw cycles.
Target Information
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Frizzled-related protein 1b; FRP-1b; SARP-3; secreted apoptosis related protein 3; Secreted apoptosis-related protein 3; Secreted frizzled-related protein 5; sFRP-5
Gene Aliases: FRP1B; SARP3; SFRP5
UniProt ID: (Human) Q5T4F7
Entrez Gene ID: (Human) 6425
apoptotic process
establishment or maintenance of cell polarity
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
visual perception
negative regulation of cell proliferation
anatomical structure morphogenesis
cell differentiation
negative regulation of Wnt signaling pathway
negative regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of protein kinase B signaling
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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