Proteintech

SGSM3 Polyclonal Antibody

SGSM3 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

SGSM3 Antibody (20825-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 20825-1-AP (SGSM3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SGSM3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SGSM3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20825-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SGSM3 Fusion Protein Ag14800 (400-749 aa encoded by BC008078)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.32 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RTQRRKSTI TALLFGEDDL EALKAKNIKQ TELVADLREA ILRVARHFQC TDPKNCSVEL TPDYSMESHQ RDHENYVACS RSHRRRAKAL LDFERHDDDE LGFRKNDIIT IVSQKDEHCW VGELNGLRGW FPAKFVEVLD ERSKEYSIAG DDSVTEGVTD LVRGTLCPAL KALFEHGLKK PSLLGGACHP WLFIEEAAGR EVERDFASVY SRLVLCKTFR LDEDGKVLTP EELLYRAVQS VNVTHDAVHA QMDVKLRSLI CVGLNEQVLH LWLEVLCSSL PTVEKWYQPW SFLRSPGWVQ IKCELRVLCC FAFSLSQDWE LPAKREAQQP LKEGVRDMLV KHHLFSWDVD G (400-749 aa encoded by BC008078)

Target Information

May play a cooperative role in NF2-mediated growth suppression of cells. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TBC1D18 is a Rab5-GAP that coordinates endosome maturation together with Mon1.

The Journal of cell biology

Hiragi S,Matsui T,Sakamaki Y,Fukuda M

Mon Dec 05 00:00:00 UTC 2022

Autophagy Contributes to Host Immunity and Protection against Zika Virus Infection via Type I IFN Signaling.

Mediators of inflammation

Huang Y,Wang Y,Meng S,Chen Z,Kong H,Pan T,Lu G,Li X

Thu Jul 08 00:00:00 UTC 2021

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.

Cell reports

Pensalfini A,Kim S,Subbanna S,Bleiwas C,Goulbourne CN,Stavrides PH,Jiang Y,Lee JH,Darji S,Pawlik M,Huo C,Peddy J,Berg MJ,Smiley JF,Basavarajappa BS,Nixon RA

Tue Nov 24 00:00:00 UTC 2020

AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.

Scientific reports

Candiello E,Kratzke M,Wenzel D,Cassel D,Schu P

Thu Jul 14 00:00:00 UTC 2016

AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.

Scientific reports

Candiello E,Kratzke M,Wenzel D,Cassel D,Schu P

Thu Jul 14 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: Cx43-interacting protein of 85-kDa; DKFZp761D051; merlin binding protein; Merlin-associated protein; Rab-GTPase-activating protein-like protein; RabGAPLP; RUN and SH3 containing 3; RUN and TBC1 domain containing 3; RUN and TBC1 domain-containing protein 3; SGSM3; Small G protein signaling modulator 3; small G protein signaling modulator 3 protein

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Gene Aliases: 1810012I01Rik; AI428557; BB175482; Cip85; MAP; R75178; RabGAP-5; RABGAP5; RABGAPLP; RUSC3; RUTBC3; SGSM3

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UniProt ID: (Human) Q96HU1, (Mouse) Q8VCZ6

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Entrez Gene ID: (Human) 27352, (Mouse) 105835

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Function(s)

GTPase activator activity protein binding Rab GTPase binding GTPase regulator activity

Process(es)

intracellular protein transport cell cycle arrest regulation of vesicle fusion regulation of Rab protein signal transduction Rap protein signal transduction plasma membrane to endosome transport activation of GTPase activity regulation of cilium assembly cell cycle positive regulation of GTPase activity positive regulation of protein catabolic process regulation of catalytic activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SGSM3 Polyclonal Antibody

SGSM3 Antibody (20825-1-AP) in ICC/IF

Product Details

20825-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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