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Product Details
22198-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SH2B3 Fusion Protein Ag17381 (1-340 aa encoded by BC136451)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNGPALQPS SPSSAPSASP AAAPRGWSEF CELHAVAAAR ELARQYWLFA REHPQHAPLR AELVSLQFTD LFQRYFCREV RDGRAPGRDY RDTGRGPPAK AEASPEPGPG PAAPGLPKAR SSEELAPPRP PGPCSFQHFR RSLRHIFRRR SAGELPAAHT AAAPGTPGEA AETPARPGLA KKFLPWSLAR EPPPEALKEA VLRYSLADEA SMDSGARWQR GRLALRRAPG PDGPDRVLEL FDPPKSSRPK LQAACSSIQE VRWCTRLEMP DNLYTFVLKV KDRTDIIFEV GDEQQLNSWM AELSECTGRG LESTEAEMHI PSALEPSTSS SPRGSTDSLN Q (1-340 aa encoded by BC136451)
Target Information
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; Signal transduction protein Lnk
Gene Aliases: IDDM20; LNK; SH2B3
UniProt ID: (Human) Q9UQQ2
Entrez Gene ID: (Human) 10019
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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