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SH3BP5 Polyclonal Antibody

SH3BP5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SH3BP5 Antibody (11127-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor using 11127-2-AP (SH3BP5 antibody) at dilution of 1:50 (under 10x lens).

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Product Details

11127-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SH3BP5 Fusion Protein Ag1592 (50-455 aa encoded by BC010123)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EKLNQSTDD INRRETELED ARQKFRSVLV EATVKLDELV KKIGKAVEDS KPYWEARRVA RQAQLEAQKA TQDFQRATEV LRAAKETISL AEQRLLEDDK RQFDSAWQEM LNHATQRVME AEQTKTRSEL VHKETAARYN AAMGRMRQLE KKLKRAINKS KPYFELKAKY YVQLEQLKKT VDDLQAKLTL AKGEYKMALK NLEMISDEIH ERRRSSAMGP RGCGVGAEGS STSVEDLPGS KPEPDAISVA SEAFEDDSCS NFVSEDDSET QSVSSFSSGP TSPSEMPDQF PAVVRPGSLD LPSPVSLSEF GMMFPVLGPR SECSGASSPE CEVERGDRAE GAENKTSDKA NNNRGLSSSS GSGGSSKSQS STSPEGQALE NRMKQLSLQC SKGRDGIIAD IKMVQIG (50-455 aa encoded by BC010123)

Target Information

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gu L,He X,Zhang Y,Li S,Tang J,Ma R,Yang X,Huang H,Peng Y,Xie Y,Peng Z,Meng J,Hu G,Tao L,Liu X,Yang H

Tue Aug 01 00:00:00 UTC 2023

Scoparone Improves Nonalcoholic Steatohepatitis Through Alleviating JNK/Sab Signaling Pathway-Mediated Mitochondrial Dysfunction.

Frontiers in pharmacology

Jiang Y,Xu J,Huang P,Yang L,Liu Y,Li Y,Wang J,Song H,Zheng P

Sat Jul 16 00:00:00 UTC 2022

Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.

Biomolecules

Li M,Hao S,Li C,Xiao H,Sun L,Yu Z,Zhang N,Xiong Y,Zhao D,Yin Y

Thu Sep 19 00:00:00 UTC 2019

Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.

Hepatology (Baltimore, Md.)

Sun Y,Li TY,Song L,Zhang C,Li J,Lin ZZ,Lin SC,Lin SY

Fri Jun 01 00:00:00 UTC 2018

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.

Journal of hepatology

Win S,Than TA,Le BH,García-Ruiz C,Fernandez-Checa JC,Kaplowitz N

Mon Jun 01 00:00:00 UTC 2015

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.

Journal of hepatology

Win S,Than TA,Le BH,García-Ruiz C,Fernandez-Checa JC,Kaplowitz N

Mon Jun 01 00:00:00 UTC 2015

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.

Cell death & disease

Win S,Than TA,Fernandez-Checa JC,Kaplowitz N

Thu Jan 09 00:00:00 UTC 2014

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.

Cell death & disease

Win S,Than TA,Fernandez-Checa JC,Kaplowitz N

Thu Jan 09 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: SH3 binding protein; SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; SH3-domain binding protein 5 (BTK-associated); SH3BP-5; Vascular endothelial cell-specific protein 18

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Gene Aliases: AI606498; SAB; SH3BP-5; SH3BP5; Vesp18

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UniProt ID: (Human) O60239, (Rat) Q91Y80, (Mouse) Q9Z131

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Entrez Gene ID: (Human) 9467, (Rat) 117186, (Mouse) 24056

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Function(s)

protein kinase inhibitor activity protein binding SH3 domain binding

Process(es)

signal transduction intracellular signal transduction negative regulation of protein tyrosine kinase activity negative regulation of protein kinase activity JNK cascade

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SH3BP5 Polyclonal Antibody

SH3BP5 Antibody (11127-2-AP) in IHC (P)

Product Details

11127-2-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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