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SH3PXD2B Antibody (PA5-116404) in WB
Western Blot analysis of SH3PXD2B using the SH3PXD2B Polyclonal Antibody (Product # PA5-116404) at a 1:2000 dilution. Lane 1: U-251 MG whole cell lysate, Lane 2: SH-SY5Y whole cell lysate, Lane 3: U-87 MG whole cell lysate, Lane 4: Hela whole cell lysate. Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution. Predicted band size : 102 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-116404
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 505-539 amino acids from the Central region of human SH3PXD2B
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901037
Target Information
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein HOFI; adaptor protein HOFI; Factor for adipocyte differentiation 49; FLJ20831; SH3 and PX domain-containing protein 2B; Tyrosine kinase substrate with four SH3 domains
Gene Aliases: FAD49; FTHS; HOFI; KIAA1295; SH3PXD2B; TKS4; TSK4
UniProt ID: (Human) A1X283
Entrez Gene ID: (Human) 285590
skeletal system development
eye development
superoxide metabolic process
heart development
extracellular matrix disassembly
cell differentiation
positive regulation of catalytic activity
positive regulation of fat cell differentiation
oxidation-reduction process
bone development
adipose tissue development
podosome assembly
protein localization to membrane
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