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Immunogen sequence: LRPVLPTQS AHDPPAVHLS NGPGQEPIAV MTFDLTKITK TSSSFEVRTW DPEGVIFYGD TNPKDDWFML GLRDGRPEIQ LHNHWAQLTV GAGPRLDDGR WHQVEVKMEG DSVLLEVDGE EVLRLRQVSG PLTSKRHPIM RIALGGLLFP ASNLRLPLVP ALDGCLRRDS WLDKQAEISA SAPTSLRSCD VESNPGIFLP PGTQAEFNLR DIPQPHAEPW AFSLDLGLKQ AAGSGHLLAL GTPENPSWLS LHLQDQKVVL SSGSGPGLDL PLVLGLPLQL KLSMSRVVLS QGSKMKALAL PPLGLAPLLN LWAKPQGRLF LGALPGEDSS TSFCLNGLWA QGQRLDVDQA LNRSHEIWTH SCPQSPGNGT DASH (30-402 aa encoded by BC101785)
SHBG is a steroid binding protein that was first described as a plasma protein secreted by the liver and is thought to participate in the regulation of steroid responses. SHBG transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Low plasma SHBG levels are associated with obesity, abdominal adiposity, metabolic syndrome, and predict the development of type 2 diabetes. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABP; Androgen binding protein (ABP); SBP; Sex hormone-binding globulin; Sex hormone-binding globulin (SHBG); Sex steroid binding protein (SBP); Sex steroid-binding protein; SHBG; TeBG; Testis-specific androgen-binding protein; Testosterone binding beta globulin; testosterone-binding beta-globulin; Testosterone-estradiol-binding globulin; Testosterone-Estradiol-Binding Globulin (TEBG); Testosterone-estrogen-binding globulin
Gene Aliases: ABP; SBP; SHBG; TEBG
UniProt ID: (Human) P04278
Entrez Gene ID: (Human) 6462
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