Invitrogen

SHC Monoclonal Antibody (OTI3A1)

View all (45) SHC antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-25076

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI3A1

Immunogen

Full length human recombinant protein of SHC1 produced in HEK293T cell
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2725350

Target Information

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ26504; OTTHUMP00000035472; RP11-307C12.1; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; src homology 2 domain-containing transforming protein C1; Src homology 2 domain-containing-transforming protein C1

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Gene Aliases: p66; P66shc; SHC; SHC1; SHCA

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UniProt ID: (Human) P29353, (Rat) Q5M824, (Mouse) P98083

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Entrez Gene ID: (Human) 6464, (Rat) 85385, (Mouse) 20416

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Function(s)
phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding phospholipid binding ephrin receptor binding protein phosphatase 2A binding protein kinase binding receptor tyrosine kinase binding protein complex binding phosphoprotein binding
Process(es)
MAPK cascade activation of MAPK activity angiogenesis response to hypoxia epidermal growth factor receptor signaling pathway heart development aging insulin receptor signaling pathway response to toxic substance response to organic cyclic compound single organismal cell-cell adhesion actin cytoskeleton organization neuron differentiation organ regeneration neuron projection development actin cytoskeleton reorganization response to insulin cellular response to insulin stimulus response to nicotine intracellular signal transduction regulation of growth regulation of cell proliferation response to hydrogen peroxide positive regulation of DNA replication positive regulation of vasoconstriction positive regulation of smooth muscle cell proliferation response to glucocorticoid regulation of epidermal growth factor-activated receptor activity Ras protein signal transduction positive regulation of cell proliferation viral process IRE1-mediated unfolded protein response Fc-epsilon receptor signaling pathway ERBB2 signaling pathway positive regulation of GTPase activity leukocyte migration cellular response to growth factor stimulus signal transduction
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