Proteintech

SHCBP1 Polyclonal Antibody

SHCBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SHCBP1 Antibody (12672-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 12672-1-AP (SHCBP1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SHCBP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12672-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SHCBP1 Fusion Protein Ag3355 (374-672 aa encoded by BC030699)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NACFEGDTV IVCPGHYVVH GTFSIADSIE LEGYGLPDDI VIEKRGKGDT FVDCTGADIK ISGIKFVQHD AVEGILIVHR GKTTLENCVL QCETTGVTVR TSAEFLMKNS DLYGAKGAGI EIYPGSQCTL SDNGIHHCKE GILIKDFLDE HYDIPKISMV NNIIHNNEGY GVVLVKPTIF SDLQESAEDG TEENKALKIQ TSGEPDVAER VDLEELIECA TGKMELCART DPSEQVEGNC EIVNELIAAS TQKGQIKKKR LSELGITQAD DNLMSQEMFV GIVGNQFKWN GKGSFGTFLF (374-672 aa encoded by BC030699)

Target Information

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SHCBP1 contributes to the proliferation and self‑renewal of cervical cancer cells and activation of the NF‑κB signaling pathway through EIF5A.

Oncology letters

Deng B,Li A,Zhu Y,Zhou Y,Fei J,Miao Y

Thu Jun 01 00:00:00 UTC 2023

Functional roles of the SHCBP1 and KIF23 interaction in modulating the cell-cycle and cisplatin resistance of head and neck squamous cell carcinoma.

Head & neck

Sun Y,Pan H,He Y,Hu C,Gu Y

Tue Mar 01 00:00:00 UTC 2022

Functional roles of the SHCBP1 and KIF23 interaction in modulating the cell-cycle and cisplatin resistance of head and neck squamous cell carcinoma.

Head & neck

Sun Y,Pan H,He Y,Hu C,Gu Y

Tue Mar 01 00:00:00 UTC 2022

Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.

Nature neuroscience

Duy PQ,Weise SC,Marini C,Li XJ,Liang D,Dahl PJ,Ma S,Spajic A,Dong W,Juusola J,Kiziltug E,Kundishora AJ,Koundal S,Pedram MZ,Torres-Fernández LA,Händler K,De Domenico E,Becker M,Ulas T,Juranek SA,Cuevas E,Hao LT,Jux B,Sousa AMM,Liu F,Kim SK,Li M,Yang Y,Takeo Y,Duque A,Nelson-Williams C,Ha Y,Selvaganesan K,Robert SM,Singh AK,Allington G,Furey CG,Timberlake AT,Reeves BC,Smith H,Dunbar A,DeSpenza T,Goto J,Marlier A,Moreno-De-Luca A,Yu X,Butler WE,Carter BS,Lake EMR,Constable RT,Rakic P,Lin H,Deniz E,Benveniste H,Malvankar NS,Estrada-Veras JI,Walsh CA,Alper SL,Schultze JL,Paeschke K,Doetzlhofer A,Wulczyn FG,Jin SC,Lifton RP,Sestan N,Kolanus W,Kahle KT

Fri Apr 01 00:00:00 UTC 2022

Effects of Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway.

Frontiers in pharmacology

Wang F,Fan J,Pei T,He Z,Zhang J,Ju L,Han Z,Wang M,Xiao W

Tue Mar 01 00:00:00 UTC 2022

SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.

Genomics

Yang C,Hu JF,Zhan Q,Wang ZW,Li G,Pan JJ,Huang L,Liao CY,Huang Y,Tian YF,Shen BY,Chen JZ,Wang YD,Chen S

Mon Mar 01 00:00:00 UTC 2021

SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.

Genomics

Yang C,Hu JF,Zhan Q,Wang ZW,Li G,Pan JJ,Huang L,Liao CY,Huang Y,Tian YF,Shen BY,Chen JZ,Wang YD,Chen S

Mon Mar 01 00:00:00 UTC 2021

SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.

Genomics

Yang C,Hu JF,Zhan Q,Wang ZW,Li G,Pan JJ,Huang L,Liao CY,Huang Y,Tian YF,Shen BY,Chen JZ,Wang YD,Chen S

Mon Mar 01 00:00:00 UTC 2021

FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells.

Cancer biology & therapy

Lu H,Yin M,Wang L,Cheng J,Cheng W,An H,Zhang T

Sun Nov 01 00:00:00 UTC 2020

Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.

International immunopharmacology

Huang H,Cai H,Zhang L,Hua Z,Shi J,Wei Y

Sun Mar 01 00:00:00 UTC 2020

Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.

International immunopharmacology

Huang H,Cai H,Zhang L,Hua Z,Shi J,Wei Y

Sun Mar 01 00:00:00 UTC 2020

SHCBP1 regulates STAT3/c-Myc signaling activation to promote tumor progression in penile cancer.

American journal of cancer research

Mo M,Tong S,Yin H,Jin Z,Zu X,Hu X

Thu Nov 12 00:00:00 UTC 2020

SHCBP1 regulates STAT3/c-Myc signaling activation to promote tumor progression in penile cancer.

American journal of cancer research

Mo M,Tong S,Yin H,Jin Z,Zu X,Hu X

Thu Nov 12 00:00:00 UTC 2020

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis.