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Invitrogen
SHH Polyclonal Antibody
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Product Details
PA5-116417
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 151-162 amino acids from the Central region of DANRE shha
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901049
Target Information
Sonic Hedgehog (SHH), which is expressed only during embryogenesis, is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the Sonic Hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; SHHA; ShhNC; sonic hedgehog a; Sonic hedgehog protein; sonic-you; VHH-1
Gene Aliases: fc83d08; shh; shha; ShhNC; syu; vhh-1; vhh1; wu:fc83d08
UniProt ID: (Zebrafish) Q92008
Entrez Gene ID: (Zebrafish) 30269
cell fate specification
somitogenesis
neural plate morphogenesis
heart looping
proteolysis
smoothened signaling pathway
cell-cell signaling
multicellular organism development
determination of left/right symmetry
nervous system development
axon guidance
central nervous system development
brain development
heart development
muscle organ development
blood circulation
negative regulation of cell proliferation
anterior/posterior pattern specification
dorsal/ventral pattern formation
glial cell differentiation
cardioblast differentiation
regulation of gene expression
intein-mediated protein splicing
floor plate formation
spinal cord motor neuron cell fate specification
diencephalon development
adenohypophysis development
habenula development
neuron differentiation
forebrain development
hindbrain development
midbrain-hindbrain boundary development
regulation of vascular endothelial growth factor receptor signaling pathway
pancreas development
endocrine pancreas development
embryonic camera-type eye development
glomerulus development
pectoral fin development
floor plate development
caudal fin morphogenesis
gliogenesis
eye photoreceptor cell development
odontogenesis
muscle cell fate specification
camera-type eye development
photoreceptor cell maintenance
embryonic digestive tract morphogenesis
post-embryonic foregut morphogenesis
neuron fate commitment
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
oligodendrocyte differentiation
skeletal muscle fiber development
pronephros development
swim bladder morphogenesis
inner ear development
striated muscle cell development
endocardial cell differentiation
regulation of cartilage development
oligodendrocyte progenitor proliferation
regulation of cardiac muscle tissue regeneration
regulation of BMP signaling pathway involved in heart jogging
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