Invitrogen

SHIP1 Recombinant Rabbit Monoclonal Antibody (2F8U0)

View all (19) SHIP1 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-42823

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2F8U0

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1084-1178 of human SHIP11 (Q92835)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.75 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911964

Product Specific Information

Positive test controls include: Raji, U-937. The target is usually found in the following locations: Cytoplasm, Membrane, Peripheral membrane protein.

Immunogen sequence: RSFTCSSSAE GRAAGGDKSQ GKPKTPVSSQ APVPAKRPIK PSRSEINQQT PPTPTPRPPL PVKSPAVLHL QHSKGRDYRD NTELPHHGKH RPEEG

Target Information

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hp51CN; Inositol polyphosphate-5-phosphatase 145 kDa; Inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; Inositol polyphosphate-5-phosphatase, 145 kDa; inositol polyphosphate-5-phosphatase, 145kD; inositol polyphosphate-5-phosphatase, 145kDa; MGC104855; MGC142140; MGC142142; OTTHUMP00000165069; OTTHUMP00000165070; OTTHUMP00000165071; OTTHUMP00000165072; OTTHUMP00000203442; p150Ship; phosphatidylin; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SH2-containing inositol phosphatase SHIP; SHIP-1; signaling inositol polyphosphate 5 phosphatase SIP-145; signaling inositol polyphosphate phosphatase SHIP II; SIP-145; Src homology 2 domain-containing inositol-5-phosphatase

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Gene Aliases: 7a33; hp51CN; INPP5D; p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1; SIP-145

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UniProt ID: (Human) Q92835, (Mouse) Q9ES52, (Rat) P97573

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Entrez Gene ID: (Human) 3635, (Mouse) 16331, (Rat) 54259

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Function(s)
inositol-polyphosphate 5-phosphatase activity protein binding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity SH3 domain binding phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity PTB domain binding inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity hydrolase activity inositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity
Process(es)
immune system process apoptotic process negative regulation of cell proliferation determination of adult lifespan negative regulation of signal transduction immunoglobulin mediated immune response dephosphorylation negative regulation of granulocyte differentiation negative regulation of B cell proliferation intracellular signal transduction positive regulation of apoptotic process negative regulation of interleukin-6 biosynthetic process positive regulation of B cell differentiation positive regulation of lymphocyte differentiation positive regulation of erythrocyte differentiation negative regulation of monocyte differentiation negative regulation of neutrophil differentiation negative regulation of osteoclast differentiation negative regulation of bone resorption phosphatidylinositol dephosphorylation negative regulation of immune response negative regulation of B cell activation phosphatidylinositol biosynthetic process phosphate-containing compound metabolic process signal transduction inositol phosphate metabolic process T cell receptor signaling pathway leukocyte migration biological_process
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