Proteintech

SIGMAR1 Polyclonal Antibody

SIGMAR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SIGMAR1 Antibody (15168-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 15168-1-AP) (SIGMAR1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

15168-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 26 publications 26 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

Assay-dependent

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SIGMAR1 Fusion Protein Ag7351 (101-223 aa encoded by BC004899)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SEYVLLFGT ALGSRGHSGR YWAEISDTII SGTFHQWREG TTKSEVFYPG ETVVHGPGEA TAVEWGPNTW MVEYGRGVIP STLAFALADT VFSTQDFLTL FYTLRSYARG LRLELTTYLF GQDP (101-223 aa encoded by B C004899)

Target Information

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.

International immunopharmacology

Huang R,Cai L,Ma X,Shen K

Sat Apr 01 00:00:00 UTC 2023

Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection.

Neural regeneration research

Wang Z,Yi XZ,Yu AX

Sat Apr 01 00:00:00 UTC 2023

Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.

Journal of neurochemistry

Liu Q,Guo Q,Fang LP,Yao H,Scheller A,Kirchhoff F,Huang W

Wed Mar 01 00:00:00 UTC 2023

Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.

Journal of neurochemistry

Liu Q,Guo Q,Fang LP,Yao H,Scheller A,Kirchhoff F,Huang W

Wed Mar 01 00:00:00 UTC 2023

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

Nature communications

Zhao Y,Hu D,Wang R,Sun X,Ropelewski P,Hubler Z,Lundberg K,Wang Q,Adams DJ,Xu R,Qi X

Wed Mar 02 00:00:00 UTC 2022

PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis.

Cellular and molecular life sciences : CMLS

Knoell J,Chillappagari S,Knudsen L,Korfei M,Dartsch R,Jonigk D,Kuehnel MP,Hoetzenecker K,Guenther A,Mahavadi P

Fri Feb 25 00:00:00 UTC 2022

A new insight on peripheral nerve repair: the technique of internal nerve splinting.

Journal of neurosurgery

Luo X,Li B,Zhang D,Chen H,Zhou X,Yao C,Raza MA,Wang L,Tang N,Zheng G,Yan H

Tue Nov 01 00:00:00 UTC 2022

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.

Pharmaceutical biology

Zhang Y,Ye G,Chen Y,Sheng C,Wang J,Kong L,Yuan L,Lin C

Thu Dec 01 00:00:00 UTC 2022

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.

Pharmaceutical biology

Zhang Y,Ye G,Chen Y,Sheng C,Wang J,Kong L,Yuan L,Lin C

Thu Dec 01 00:00:00 UTC 2022

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.

Pharmaceutical biology

Zhang Y,Ye G,Chen Y,Sheng C,Wang J,Kong L,Yuan L,Lin C

Thu Dec 01 00:00:00 UTC 2022

Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells.

Molecular medicine reports

Ke M,Lin F,Wang H,He G,Feng J,Song L,Xu Y,Liu J

Sun May 01 00:00:00 UTC 2022

A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.

Acta neuropathologica

Shang Y,Sun X,Chen X,Wang Q,Wang EJ,Miller E,Xu R,Pieper AA,Qi X

Tue Nov 01 00:00:00 UTC 2022

Serine palmitoyltransferase assembles at ER-mitochondria contact sites.

Life science alliance

Aaltonen MJ,Alecu I,König T,Bennett SA,Shoubridge EA

Tue Feb 01 00:00:00 UTC 2022

Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.

Human molecular genetics

Crouzier L,Richard EM,Diez C,Alzaeem H,Denus M,Cubedo N,Delaunay T,Glendenning E,Baxendale S,Liévens JC,Whitfield TT,Maurice T,Delprat B

Tue Aug 23 00:00:00 UTC 2022

Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.

Experimental neurology

Liu D,Yang L,Liu P,Ji X,Qi X,Wang Z,Chi T,Zou L

Sat Jan 01 00:00:00 UTC 2022

Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.

Experimental neurology

Liu D,Yang L,Liu P,Ji X,Qi X,Wang Z,Chi T,Zou L

Sat Jan 01 00:00:00 UTC 2022

Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.

Experimental neurology

Liu D,Yang L,Liu P,Ji X,Qi X,Wang Z,Chi T,Zou L

Sat Jan 01 00:00:00 UTC 2022

Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF-GFRα1-RET pathway.

Experimental neurology

Liu D,Yang L,Liu P,Ji X,Qi X,Wang Z,Chi T,Zou L

Sat Jan 01 00:00:00 UTC 2022

Allosteric Modulation of the Sigma-1 Receptor Elicits Antipsychotic-like Effects.

Schizophrenia bulletin

Chen J,Li G,Qin P,Chen J,Ye N,Waddington JL,Zhen X

Tue Mar 01 00:00:00 UTC 2022

Nerve-End Capping Treatment with a Polyglycolic Acid Conduit for Rat Sciatic Neuroma: A Preliminary Report.

Journal of reconstructive microsurgery

Onode E,Uemura T,Hama S,Yokoi T,Okada M,Takamatsu K,Nakamura H

Tue Nov 01 00:00:00 UTC 2022

NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome.

Molecular therapy. Methods & clinical development

Crouzier L,Richard EM,Diez C,Denus M,Peyrel A,Alzaeem H,Cubedo N,Delaunay T,Maurice T,Delprat B

Thu Dec 08 00:00:00 UTC 2022

The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.

Journal of cell science

Han S,Zhao F,Hsia J,Ma X,Liu Y,Torres S,Fujioka H,Zhu X

Thu Jul 01 00:00:00 UTC 2021

Sulforaphane Balances Ca²⁺ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).

Molecular nutrition & food research

Tian S,Lei P,Zhang J,Sun Y,Li B,Shan Y

Thu Jul 01 00:00:00 UTC 2021

Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.

Neuropharmacology

Wang M,Wan C,He T,Han C,Zhu K,Waddington JL,Zhen X

Wed Sep 15 00:00:00 UTC 2021

Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.

International journal of molecular sciences

Crouzier L,Denus M,Richard EM,Tavernier A,Diez C,Cubedo N,Maurice T,Delprat B

Wed Oct 13 00:00:00 UTC 2021

Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate.

Experimental biology and medicine (Maywood, N.J.)

Ke M,He G,Wang H,Cheng S,Xu Y

Thu Jul 01 00:00:00 UTC 2021

Nerve capping treatment using a bioabsorbable nerve conduit with open or closed end for rat sciatic neuroma.

Clinical neurology and neurosurgery

Hama S,Uemura T,Onode E,Yokoi T,Okada M,Takamatsu K,Nakamura H

Fri Oct 01 00:00:00 UTC 2021

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.

Molecular neurobiology

Ooi K,Hu L,Feng Y,Han C,Ren X,Qian X,Huang H,Chen S,Shi Q,Lin H,Wang J,Zhu D,Wang R,Xia C

Wed Dec 01 00:00:00 UTC 2021

Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.

Molecular neurobiology

Ooi K,Hu L,Feng Y,Han C,Ren X,Qian X,Huang H,Chen S,Shi Q,Lin H,Wang J,Zhu D,Wang R,Xia C

Wed Dec 01 00:00:00 UTC 2021

Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS.

The Journal of cell biology