Invitrogen

SIN3A Recombinant Rabbit Monoclonal Antibody (JA94-31)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-32720

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JA94-31

Immunogen

Synthetic peptide within Human mSin3A aa 1224-1273
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809997

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Mammalian Sin3 (mSin3) is a 150 kDa protein closely related to the yeast SIN3 repressor protein involved in the transcriptional repression of many genes. There are two mammalian isoforms, mSin3A and mSin3B. Containing 4 paired amphipathic helix domains (PAH domains), mSin3A and mSin3B have been shown to directly interact with several other transcriptional repressor proteins including HDAC1, HDAC2, RbAp46, the methyl CpG binding protein MeCP2, the Mad/Max heterodimer, and the corepressors silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Histone deacetylase complex subunit Sin3a; Mammalian Sin3A; Paired amphipathic helix protein Sin3a; SIN; SIN3 homolog A, transcription regulator; SIN3 transcription regulator homolog A; SIN3A; transcriptional co-repressor Sin3A; Transcriptional corepressor Sin3a; transcriptional regulator, SIN3 yeast homolog A; transcriptional regulator, SIN3A

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Gene Aliases: AW553200; Kiaa4126; mKIAA4126; mSin3A; Sin3; SIN3A

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UniProt ID: (Human) Q96ST3, (Mouse) Q60520

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Entrez Gene ID: (Human) 25942, (Rat) 363067, (Mouse) 20466

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II repressing transcription factor binding RNA polymerase II transcription corepressor activity chromatin binding transcription factor activity, sequence-specific DNA binding RNA binding histone deacetylase activity protein binding protein complex binding protein deacetylase activity DNA binding transcription corepressor activity transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development activation of innate immune response positive regulation of defense response to virus by host hematopoietic progenitor cell differentiation DNA replication transcription, DNA-templated protein deacetylation aging regulation of hormone levels positive regulation of G2/M transition of mitotic cell cycle histone deacetylation positive regulation of chromatin silencing cellular protein localization negative regulation of circadian rhythm negative regulation of apoptotic process regulation of transcription from RNA polymerase II promoter in response to oxidative stress cellular lipid metabolic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process response to methylglyoxal cellular response to glucose stimulus negative regulation of protein localization to nucleus negative regulation of histone H3-K27 acetylation cellular response to dopamine negative regulation of transcription regulatory region DNA binding regulation of transcription, DNA-templated transcription from RNA polymerase II promoter response to organonitrogen compound
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