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Invitrogen
SIRP alpha Monoclonal Antibody (MRC OX-41), FITC
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SIRP alpha Antibody (MA1-90103) in Flow
Journal of inflammation research 2024 -
Impact of QLY treatment on immune milieu in AIA rats. ( A ) Flow cytometry analysis of CD3 + CD4 + IL-17alpha + Th17 cells in peripheral blood sampled on day 18; ( B ) flow cytometry analysis of inflammatory CD43 + CD86 + monocytes in peripheral blood sampled on day 18; ( C ) mRNA expression of iNOS, IL-1beta, MCP-1, IL-10, Arg-1, SIRT1 in peripheral WBCs collected on day 18 and 28 assessed by RT-qPCR; ( D ... View More
Product Details
MA1-90103
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MRC OX-41
Immunogen
Rat peritoneal macrophages.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
IgG fraction
Storage buffer
PBS with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1955115
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells. SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs. SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes. Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bit; Brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 alpha; CD172 antigen-like family member A; CD172a; Inhibitory receptor SHPS-1; Macrophage fusion receptor; Macrophage membrane protein MFP150; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); SHP substrate 1; Signal-regulatory protein alpha-1; Sirp-alpha-1; SIRPalpha; SIRPalpha2; Tyrosine-protein phosphatase non-receptor type substrate 1
Gene Aliases: Bit; Mfr; Ptpns1; SHPS-1; Shps1; Sirp; Sirpa
UniProt ID: (Rat) P97710
Entrez Gene ID: (Rat) 25528
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