Invitrogen

SIRT2 Recombinant Rabbit Monoclonal Antibody (SN70-04)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32320

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SN70-04

Immunogen

Synthetic peptide within Human SIRT2 aa 335-389
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809602

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5E5 antigen; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; SIR2-like protein 2; sir2-related protein type 2; sirtuin type 2; sirtuin-2

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Gene Aliases: SIR2; SIR2L; SIR2L2; SIRT2

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UniProt ID: (Human) Q8IXJ6

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Entrez Gene ID: (Human) 22933, (Rat) 361532

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Function(s)
chromatin binding NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding transcription factor binding zinc ion binding NAD-dependent histone deacetylase activity protein deacetylase activity NAD-dependent protein deacetylase activity histone acetyltransferase binding histone deacetylase binding tubulin deacetylase activity ubiquitin binding NAD-dependent histone deacetylase activity (H4-K16 specific) beta-tubulin binding NAD+ binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated protein deacetylation autophagy mitotic nuclear division central nervous system development negative regulation of cell proliferation negative regulation of autophagy negative regulation of peptidyl-threonine phosphorylation phosphatidylinositol 3-kinase signaling histone deacetylation substantia nigra development myelination in peripheral nervous system regulation of myelination positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to oxidative stress peptidyl-lysine deacetylation cellular response to hepatocyte growth factor stimulus negative regulation of protein catabolic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding protein kinase B signaling cellular lipid catabolic process regulation of fat cell differentiation negative regulation of fat cell differentiation positive regulation of meiotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway negative regulation of oligodendrocyte differentiation cell division meiotic cell cycle regulation of cell cycle positive regulation of cell division positive regulation of attachment of spindle microtubules to kinetochore negative regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to caloric restriction negative regulation of oligodendrocyte progenitor proliferation histone H3 deacetylation histone H4 deacetylation cellular response to molecule of bacterial origin cellular response to hypoxia cellular response to epinephrine stimulus tubulin deacetylation positive regulation of execution phase of apoptosis positive regulation of oocyte maturation negative regulation of NLRP3 inflammasome complex assembly negative regulation of defense response to bacterium ripoptosome assembly involved in necroptotic process negative regulation of reactive oxygen species metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia chromatin silencing at rDNA chromatin silencing chromatin silencing at telomere protein ADP-ribosylation regulation of exit from mitosis gene silencing regulation of phosphorylation innate immune response response to redox state
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