Fabgennix

SIRT5 Polyclonal Antibody, FITC

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

SIRT5-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Chicken, Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 260-310 on rat Sirtuin 5 protein.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ36950; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}; Regulatory protein SIR2 homolog 5; regulatory protein SIR2 homolog 5 {ECO:0000255|HAMAP-Rule:MF_03160}; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIR2-like protein 5 {ECO:0000255|HAMAP-Rule:MF_03160}; SIRT5; sirtuin type 5

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Gene Aliases: 0610012J09Rik; 1500032M05Rik; AV001953; SIR2L5; SIRT5

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UniProt ID: (Human) Q9NXA8, (Chicken) E1BRE2, (Mouse) Q8K2C6, (Rat) Q68FX9

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Entrez Gene ID: (Human) 23408, (Chicken) 420834, (Mouse) 68346, (Rat) 306840

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Function(s)
NAD+ ADP-ribosyltransferase activity zinc ion binding protein-malonyllysine demalonylase activity protein-succinyllysine desuccinylase activity protein-glutaryllysine deglutarylase activity NAD+ binding histone deacetylase activity protein binding protein-N-terminal asparagine amidohydrolase activity UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity hydrolase activity iprodione amidohydrolase activity (3,5-dichlorophenylurea)acetate amidohydrolase activity 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity didemethylisoproturon amidohydrolase activity N-isopropylacetanilide amidohydrolase activity N-cyclohexylformamide amidohydrolase activity isonicotinic acid hydrazide hydrolase activity cis-aconitamide amidase activity gamma-N-formylaminovinylacetate hydrolase activity N2-acetyl-L-lysine deacetylase activity O-succinylbenzoate synthase activity indoleacetamide hydrolase activity N-acetylcitrulline deacetylase activity metal ion binding N-acetylgalactosamine-6-phosphate deacetylase activity diacetylchitobiose deacetylase activity chitooligosaccharide deacetylase activity molecular_function
Process(es)
chromatin silencing protein ADP-ribosylation protein deacetylation regulation of ketone biosynthetic process negative regulation of cardiac muscle cell apoptotic process response to nutrient levels protein demalonylation peptidyl-lysine demalonylation protein desuccinylation peptidyl-lysine desuccinylation protein deglutarylation peptidyl-lysine deglutarylation negative regulation of reactive oxygen species metabolic process
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