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Invitrogen
SIX1 Polyclonal Antibody
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SIX1 Antibody (PA5-95341) in WB
Western blot analysis of SIX1 in MCF-7 whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Samples were incubated with SIX1 polyclonal antibody (Product # PA5-95341) using a 0.5 µg/mL dilution. developed was performed using enhanced chemiluminescence (ECL).
Product Details
PA5-95341
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human SIX1 (245-282aa NYSLPGLTASQPSHGLQTHQHQLQDSLLGPLTSSLVDL).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807144
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 whole cell, 22RV1 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein SIX1; Sine oculis homeobox homolog 1
Gene Aliases: BOS3; DFNA23; SIX1; TIP39
UniProt ID: (Human) Q15475
Entrez Gene ID: (Human) 6495
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
organ induction
kidney development
outflow tract morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
pattern specification process
skeletal muscle tissue development
sensory perception of sound
cell proliferation
regulation of synaptic growth at neuromuscular junction
regulation of skeletal muscle satellite cell proliferation
facial nerve morphogenesis
epithelial cell differentiation
thyroid gland development
olfactory placode formation
regulation of protein localization
protein localization to nucleus
aorta morphogenesis
inner ear morphogenesis
middle ear morphogenesis
negative regulation of neuron apoptotic process
regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
thymus development
neuron fate specification
generation of neurons
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
inner ear development
regulation of epithelial cell proliferation
myoblast migration
pharyngeal system development
myotome development
fungiform papilla morphogenesis
trigeminal ganglion development
otic vesicle development
metanephric mesenchyme development
regulation of branch elongation involved in ureteric bud branching
positive regulation of ureteric bud formation
mesonephric tubule formation
ureter smooth muscle cell differentiation
positive regulation of secondary heart field cardioblast proliferation
cochlea morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
positive regulation of mesenchymal cell proliferation involved in ureter development
regulation of skeletal muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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