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Invitrogen
SIX3/SIX6 Polyclonal Antibody
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Product Details
PA5-75220
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 201-250 of Human Six3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718948
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Two of these family members Six3 and Six6 (also designated Optx2 and Six9) are required for the specification and proliferation of the eye field in vertebrates, and, therefore, are the vertebrate homologues most closely related to the Drosophila sine oculis protein, which has an essential role in controlling compound eye development. Six3 and Six6 expression largely overlap during development of specific tissues, such as retina, hypothalamus, and pituitary. Deletion of Six3 may be associated with HPE2 disorder, a common, severe malformation of the brain that results from incomplete cleavage of the forebrain during early embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein SIX3; Homeobox protein SIX6; Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 3; Sine oculis homeobox homolog 6; sine oculis homeobox protein 6; sine oculis homeobox-like protein 3; sine oculis homeobox-like protein 6; sine oculis-related homeobox 3 homolog; sine oculis-related homeobox 6 homolog; Six9 protein
Gene Aliases: E130112M24Rik; HPE2; MCOPCT2; ODRMD; OPTX2; SIX3; Six3a; Six3alpha; Six3b; Six3beta; SIX6; SIX9
UniProt ID: (Human) O95343, (Human) O95475, (Mouse) Q62233, (Mouse) Q9QZ28
Entrez Gene ID: (Human) 6496, (Human) 4990, (Mouse) 20473, (Rat) 78974, (Mouse) 20476, (Rat) 314221
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription corepressor binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
histone deacetylase binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
receptor binding
sequence-specific DNA binding
eye development
transcription from RNA polymerase II promoter
visual perception
organ morphogenesis
positive regulation of transcription from RNA polymerase II promoter
multicellular organism development
protein import into nucleus, translocation
epithelial cell maturation
lens development in camera-type eye
optic vesicle morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
protein import into nucleus
brain development
proximal/distal axis specification
neuroblast differentiation
diencephalon development
telencephalon development
forebrain anterior/posterior pattern specification
forebrain dorsal/ventral pattern formation
cell proliferation in forebrain
telencephalon regionalization
pituitary gland development
negative regulation of Wnt signaling pathway
regulation of cell proliferation
camera-type eye development
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
circadian behavior
lens induction in camera-type eye
regulation of neural retina development
lens fiber cell differentiation
neuroblast migration
regulation of cell cycle phase transition
regulation of neuroblast proliferation
apoptotic process involved in development
lens fiber cell apoptotic process
regulation of neural precursor cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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