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Invitrogen
SLC16A2 Polyclonal Antibody
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Product Details
PA5-82084
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC16A2
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2789245
Product Specific Information
Immunogen sequence: SSRNKYQPQS GSSGPSSHSP PAAMALQSQA SEEAKGPWQE ADQEQQEPVG SPEPESEPEP EPEPEPVPVP PPEPQPEPQP LPDPAPLPEL EFESERVHEP EPT
Target Information
Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiency (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MCT 7; MCT 8; monocarboxylate transporter; Monocarboxylate transporter 7; Monocarboxylate transporter 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); Solute carrier family 16 member 2; solute carrier family 16, member 2 (thyroid hormone transporter); X-linked PEST-containing transporter
Gene Aliases: AHDS; AW105741; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; MRX22; SLC16A2; XPCT
UniProt ID: (Human) P36021, (Mouse) O70324
Entrez Gene ID: (Human) 6567, (Mouse) 20502
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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