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Invitrogen
SLC22A17 Polyclonal Antibody
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Product Details
PA5-20543
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide near the carboxy terminus of the human Slc22A17.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153078
Product Specific Information
A suggested positive control is SK-N-SH cell lysate.
PA5-20543 can be used with blocking peptide PEP-0663.
Target Information
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 24p3 receptor; 24p3R; brain-specific organic ion transporter; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NGAL receptor; NgalR; organic cation transporter BOCT; potent brain type organic ion transporter; solute carrier family 22 (organic cation transporter), member 17; Solute carrier family 22 member 17; solute carrier family 22, member 17
Gene Aliases: 1700094C23Rik; 24p3R; AU041908; AW555662; BOCT; BOIT; hBOIT; mBOCT; NGALR; NGALR2; NGALR3; rBOCT; SLC22A17
UniProt ID: (Human) Q8WUG5, (Mouse) Q9D9E0, (Rat) Q9P290
Entrez Gene ID: (Human) 51310, (Mouse) 59049, (Rat) 305886
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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