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Alomone Labs, LTD
SLC22A2 (OCT2) Polyclonal Antibody
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FIGURE: 1 / 3
SLC22A2 (OCT2) Antibody (ACT-020-200UL) in IHC (F)
Expression of OCT2 in rat medial septum nucleus. Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-SLC22A2 (OCT2) Antibody (#ACT-020), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. OCT2 immunoreactivity (green) appears in neurons (arrows). B. Pre-incubation of the Antibody with SLC22A2 (OCT2) Blocking Peptide (BLP-CT020), suppressed staining. Cell nuclei are sta... View More
Product Details
ACT-020-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(CN)LTADEDTGMKLNPS, corresponding to amino acid residues 321-334 of mouse SLC22A2, Intracellular, 3rd loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-Oct; mOCT2; Organic cation transporter 2; rOCT2; Solute carrier family 22 member 2; solute carrier family 22, member 2
Gene Aliases: OCT2; OCT2r; Orct2; rOCT2; Slc22a2
UniProt ID: (Rat) Q9R0W2, (Mouse) O70577
Entrez Gene ID: (Rat) 29503, (Mouse) 20518
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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