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Invitrogen
SLC22A4 Polyclonal Antibody
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FIGURE: 1 / 1
SLC22A4 Antibody (PA5-87939) in WB
Western blot analysis of SLC22A4 in extracts of various cell lines. Samples were incubated with SLC22A4 Polyclonal antibody (Product # PA5-87939) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-87939
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 42-141 of human SLC22A4 (NP_0030502)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2804522
Product Specific Information
Immunogen sequence: LAGTPEHRCR VPDAANLSSA WRNNSVPLRL RDGREVPHSC SRYRLATIAN FSALGLEPGR DVDLGQLEQE SCLDGWEFSQ DVYLSTVVTE WNLVCEDNWK; Positive Samples: SW480, HL-60, NCI-H460, LO2, HeLa, Mouse kidney, Mouse liver, Rat liver; Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ergothioneine transporter; ET transporter; integral membrane transport protein; LSTP-Like 2; OCTN1; organic cation transporter 1; organic cation transporter OCTN1; Organic cation/carnitine transporter 1; solute carrier family (organic cation transporter), member 4; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; Solute carrier family 22 member 4
Gene Aliases: ETT; OCTN1; SLC22A4; UT2H
UniProt ID: (Human) Q9H015, (Rat) Q9R141, (Mouse) Q9Z306
Entrez Gene ID: (Human) 6583, (Rat) 64037, (Mouse) 30805
nucleotide binding
protein binding
ATP binding
secondary active organic cation transmembrane transporter activity
carnitine transmembrane transporter activity
symporter activity
cation:cation antiporter activity
quaternary ammonium group transmembrane transporter activity
PDZ domain binding
organic cation transmembrane transporter activity
transporter activity
ion transmembrane transporter activity
transmembrane transporter activity
triglyceride metabolic process
sodium ion transport
body fluid secretion
carnitine metabolic process
organic cation transport
quaternary ammonium group transport
carnitine transport
cation transmembrane transport
carnitine transmembrane transport
amino acid transmembrane transport
ion transmembrane transport
modified amino acid transport
transport
ion transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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