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Invitrogen
SLC24A2 Polyclonal Antibody
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SLC24A2 Antibody (PA5-104164) in IHC (P)
Immunohistochemistry analysis of SLC24A2 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SLC24A2 polyclonal antibody (Product # PA5-104164) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104164
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC24A2(Accession Q9UI40), corresponding to amino acid residues P311-L361.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853492
Product Specific Information
Antibody detects endogenous levels of total SLC24A2.
Target Information
NCKX2, also designated solute carrier family 24, member 2 (SLC24A2), belongs to a family of potassium-dependent sodium/calcium exchangers, all of which contain two large hydrophilic loops and two sets of multiple transmembrane-spanning segments. NCKX2 is expressed in neurons throughout the brain, with high expression found in cone photoreceptors in the retina as well as hippocampal pyramidal cells and the deep nuclei of the cerebellum. A critical component in the process of light adaptation, NCKX2 transports one calcium ion and one potassium ion in exchange for four sodium ions, thereby contolling calcium concentration in the eye during light and darkness. Additionally, NCKX2 regulates calcium levels in other cellular locations that experience rapid calcium fluxes, such as neuronal synapses. Inactivation of NCKX2 is believed to be an important regulatory mechanism in the control of sodium and calcium levels under different physiological conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)/K(+)/Ca(2+)-exchange protein 2; potassium-dependent sodium-calcium exchanger; Retinal cone Na-Ca+K exchanger; Sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; Solute carrier family 24 member 2; solute carrier family 24, member 2
Gene Aliases: 2810021B17Rik; 6330417K15Rik; AI847460; NCKX2; SLC24A2
UniProt ID: (Human) Q9UI40, (Mouse) Q8BUN9, (Rat) O54701
Entrez Gene ID: (Human) 25769, (Mouse) 76376, (Rat) 84550
ion transport
potassium ion transport
cellular calcium ion homeostasis
visual perception
learning
memory
ion transmembrane transport
sodium ion transmembrane transport
response to stimulus
long-term synaptic potentiation
long term synaptic depression
calcium ion transmembrane transport
calcium ion transport
potassium ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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