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Invitrogen
SLC25A33 Polyclonal Antibody
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Product Details
PA5-21793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human SLC25A33. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155008
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (87%), Rat (88%), Sheep (97%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The SLC25A33 gene belongs to the solute carrier family 25 (SLC25), which is the largest family of mitochondrial transport proteins comprising 53 members. The SLC25A33 gene encodes a mitochondrial transporter responsible for the transport of pyrimidine nucleotides, specifically deoxyadenine nucleotides, across the inner mitochondrial membrane. This transport is crucial for nucleotide salvage pathways, ensuring the synthesis and maintenance of mitochondrial DNA. SLC25A33 also plays a significant role in cellular energy metabolism, linking cytosolic and mitochondrial nucleotide pools. Mutations or dysregulation of this gene can impact mitochondrial function and have been implicated in various metabolic disorders and mitochondrial diseases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMSC-MCP; Bone marrow stromal cell mitochondrial carrier protein; huBMSC-MCP; mitochondrial carrier protein; novel mitochondrial carrier protein; PNC1 protein; Protein PNC1; solute carrier family 25 (pyrimidine nucleotide carrier), member 33; Solute carrier family 25 member 33; solute carrier family 25, member 33
Gene Aliases: BMSC-MCP; PNC1; SLC25A33
UniProt ID: (Human) Q9BSK2
Entrez Gene ID: (Human) 84275
mitochondrial genome maintenance
regulation of oxidative phosphorylation
mitochondrial DNA replication
transcription from mitochondrial promoter
translation
pyrimidine nucleotide transport
mitochondrion organization
positive regulation of cell proliferation
positive regulation of cell growth
mitochondria-nucleus signaling pathway
cellular response to insulin stimulus
mitochondrial respiratory chain complex III assembly
regulation of mitochondrial membrane potential
regulation of cell cycle arrest
regulation of reactive oxygen species biosynthetic process
cellular response to insulin-like growth factor stimulus
mitochondrial pyrimidine nucleotide import
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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