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Proteintech
SLC25A36 Monoclonal Antibody (1E5E4)
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Product Details
67896-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E5E4
Immunogen
SLC25A36 Fusion Protein Ag23894
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The SLC25A36 gene is part of the solute carrier family 25 (SLC25), which encodes mitochondrial transport proteins. SLC25A36 specifically functions as a transporter of pyrimidine nucleotides, including deoxynucleotide triphosphates, across the inner mitochondrial membrane. This transport is essential for maintaining mitochondrial DNA synthesis and repair, as well as for the proper functioning of mitochondrial ribonucleotide reductase. The SLC25A36 protein exhibits a characteristic transmembrane structure with six transmembrane helices and a central substrate-binding site. It operates via a mechanism involving substrate binding, conformational changes, and alternating access to the substrate-binding site from either side of the membrane. Dysregulation or mutations in SLC25A36 can lead to mitochondrial dysfunction and are associated with various metabolic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: solute carrier family 25 (pyrimidine nucleotide carrier ), member 36; solute carrier family 25 (pyrimidine nucleotide carrier), member 36; Solute carrier family 25 member 36; solute carrier family 25, member 36
Gene Aliases: C330005L02Rik; PNC2; SLC25A36
UniProt ID: (Human) Q96CQ1, (Mouse) Q922G0
Entrez Gene ID: (Human) 55186, (Mouse) 192287, (Rat) 501039
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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